Iplasma IL6, Procalcitonin and VEGF and Dialysate Level in CAPD Patients

Chronic Kidney Disease Clinical Trial

Official title:

Interleukin-6, Procalcitonin and Vascular Endothelial Growth Factor in Plasma and Dialysate Correlate With Peritoneal Solute Transport and Dialysis Adequacy in CAPD Patients

Clinical Trial Details — Status: Completed

Administrative data

• NCT number: NCT02881892
• Other study ID #: 041/57
• Status: Completed
• Phase: N/A
• First received: August 18, 2016
• Last updated: August 26, 2016
• Start date: March 2012
• Est. completion date: June 2014

Study information

• Verified date: August 2016
• Source: Bangkok Metropolitan Administration Medical College and Vajira Hospital
• Contact: n/a
• Is FDA regulated: No
• Health authority: Thailand: Ethical Committee
• Study type: Observational

Clinical Trial Summary

The aim of study was to evaluated the correlation between plasma levels, dialysate appearance rate of VEGF, inflammatory cytokines (IL- 6, procalcitonin) and PSTR, dialysis adequacy in CAPD patients.

Description:

This cross -sectional study measured IL-6, procalcitonin and VEGF level in plasma and overnight effluent. PSTR of small solutes was evaluated by standard peritoneal equilibration test (standard PET). Weekly Kt/V and creatinine clearance (CCr ) were evaluated in all patients.

Recruitment information / eligibility

• Status: Completed
• Enrollment: 26
• Est. completion date: June 2014
• Est. primary completion date: May 2014
• Accepts healthy volunteers: No
• Gender: Both
• Age group: 18 Years to 80 Years

Eligibility

Inclusion Criteria:

• Stable CAPD patients without previous history of peritonitis

Exclusion Criteria:

• HIV

• Other infections, tuberculosis or on immunosuppressive drugs,

• Autoimmune disease,

• Cancer

• Diagnosis of permanent ultrafiltration failure .

Study Design

Observational Model: Case-Only, Time Perspective: Cross-Sectional

Related Conditions & MeSH terms

• Chronic Kidney Disease
• Kidney Diseases
• Renal Insufficiency, Chronic

Intervention

Other:
• Measure plasma and dialysate level of IL-6, procalcitonin and VEGF
correlation between plasma levels, dialysate appearance rate of VEGF, inflammatory cytokines (IL- 6, procalcitonin) and PSTR, dialysis adequacy in CAPD patients.

Locations

Country	Name	City	State
Thailand	Renal Unit, BMA Medical College and Vajira Hospital	Bangkok

Sponsors (1)

Lead Sponsor	Collaborator
Bangkok Metropolitan Administration Medical College and Vajira Hospital

Country where clinical trial is conducted

Thailand, 

References & Publications (5)

Alscher DM, Mettang T. Procalcitonin in peritoneal dialysis--a useful marker of inflammation? Perit Dial Int. 2005 Sep-Oct;25(5):441-4. — View Citation

Guz G, Colak B, Hizel K, Reis KA, Erten Y, Bali M, Sindel S. Procalcitonin and conventional markers of inflammation in peritoneal dialysis patients and peritonitis. Perit Dial Int. 2006 Mar-Apr;26(2):240-8. — View Citation

Herget-Rosenthal S, Klein T, Marggraf G, Hirsch T, Jakob HG, Philipp T, Kribben A. Modulation and source of procalcitonin in reduced renal function and renal replacement therapy. Scand J Immunol. 2005 Feb;61(2):180-6. — View Citation

Oh KH, Jung JY, Yoon MO, Song A, Lee H, Ro H, Hwang YH, Kim DK, Margetts P, Ahn C. Intra-peritoneal interleukin-6 system is a potent determinant of the baseline peritoneal solute transport in incident peritoneal dialysis patients. Nephrol Dial Transplant. 2010 May;25(5):1639-46. doi: 10.1093/ndt/gfp670. Epub 2010 Jan 8. — View Citation

Pecoits-Filho R, Araújo MR, Lindholm B, Stenvinkel P, Abensur H, Romão JE Jr, Marcondes M, De Oliveira AH, Noronha IL. Plasma and dialysate IL-6 and VEGF concentrations are associated with high peritoneal solute transport rate. Nephrol Dial Transplant. 20 — View Citation

Outcome

Type	Measure	Description	Time frame	Safety issue
Primary	plasma level of VEGF, IL-6 and procalcitonin with the PSTR and dialysis adequacy in CAPD patients	measure in pg/ml	2 years	Yes
Secondary	Cytokines in diabetic and non-diabetic group	All cytokines in plasma and blood	2 years	Yes