Chronic Kidney Disease Clinical Trial
Official title:
Evaluation of the Bleeding Risk in Patient Undergoing Hemodialysis by the Analysis of Platelet Function by PFA-100®
The objective is to evaluate the function of the platelet in patients undergoing
hemodialysis. The investigators will use the assay called PFA-100, an in vitro whole blood
assay with three pathways of platelet activation to describe a platelet response profile.
The hypothesis is that patients undergoing hemodialysis present a platelet dysfunction, that
may be reversed by hemodialysis. The effect of heparin, used during hemodialysis session to
anticoagulate the hemodialyzer, on platelet function will be assessed.
The aim of this study is to evaluate the platelet function during hemodialysis. One hundred
patients with end-stage renal disease undergoing hemodialysis (2 to 3 sessions per week, 3 to
4 hours per session) will be included.
Patients who meet the inclusion criteria will be included after oral and written information
and signature of written consent.
The study consists in recording clinical and biological and the evaluation of platelet
function by the PFA-100 assay. This is a whole blood platelet function assay, with 3 pathways
of platelet activation (collagen-epinephrine, collagen-ADP and specific P2Y cartridge -
Innovance®).
Whole blood is collected in the arterial line of the arteriovenous vascular access (fistula
or graft) before and after the hemodialysis session.
PFA-100 is assayed within 2 hours after blood collection and the platelet response profile is
interpreted according to the manufacturers instructions.
Clinical informations, especially hemorragic and thrombotic history, are collected the day of
inclusion and 6 months after inclusion.
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