Chronic Kidney Disease Clinical Trial
Official title:
Furosemide Stress Test as a Predictor of Tubular Atrophy and Interstitial Fibrosis in Patients With Chronic Kidney Disease
In kidney diseases, tubule-interstitium has become much more relevant, as formerly only the glomerulus was considered to have the main importance. Kidney's tubular atrophy and interstitital fibrosis is now recognized as long term prognostic value. We aim to evaluate the function of the kidney's tubule-interstitium through furosemide excretion after intravenous administration of this drug, and correlate the rate of excretion of furosemide with interstitial fibrosis findings in scheduled kidney biopsy for patients with chronic kidney disease.
All patients scheduled for kidney biopsy will be invited to participate in a standard
isovolemic furosemide stress test before the biopsy procedure. The latter will consist in
1.5 miligrams per kilogram of weight of intravenous furosemide administration, with urinary
output follow up and measurement. The urinary output will be replaced intravenously with
normal saline to avoid dehydration and/or hypotension. A standard 5ml sample of blood will
be taken before the test and aliquots of urine before and after furosemide administration
will be frozen.
After completion of the formely mentioned test, patients will proceed to their scheduled
kidney biopsy along with interventions considered appropiate by their attending physician.
Kidney biopsy sample will be examined by histopathology service and the degree of
interstitial fibrosis will be described. The degree of fibrosis will be correlated with the
degree furosemide excretion and urinary output.
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Endpoint Classification: Pharmacokinetics/Dynamics Study, Intervention Model: Single Group Assignment, Masking: Open Label, Primary Purpose: Diagnostic
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