Usefulness of Neutrophil Gelatinase-associated Lipocalin(NGAL) to Confirm Acute Kidney Function Decrease of the Patients Who Had Non-cardiac Surgery

Chronic Kidney Disease Clinical Trial

Clinical Trial Details — Status: Completed

Administrative data

• NCT number: NCT02233010
• Other study ID #: postOPNGAL01
• Status: Completed
• Phase: N/A
• First received: September 1, 2014
• Last updated: September 5, 2014
• Start date: February 2014

Study information

• Verified date: September 2014
• Source: Inje University
• Contact: n/a
• Is FDA regulated: No
• Health authority: Korea: Food and Drug Administration
• Study type: Observational

Clinical Trial Summary

Although post-op renal function decrease is determined by serum creatinine, serum creatinine has disadvantages that it increases a long time after renal function decrease and it has various increasing time based on the level of renal function. Neutrophil Gelatinase-associated Lipocalin (NGAL's) usefulness as an evidence for acute kidney damage occurring from post-op cardiac surgery, being critical patients and contrast medium use is already proven.

But NGAL's usefulness for renal function after non-cardiac surgery is not proven and especially, NGAL's usefulness for renal injury after non-cardiac surgery in chronic renal disease patients is not proven.Therefore, the investigators will study about renal function decrease after non-cardiac surgery with NGAL and serum creatinine.

Recruitment information / eligibility

• Status: Completed
• Enrollment: 43
• Est. primary completion date: August 2014
• Accepts healthy volunteers: No
• Gender: Both
• Age group: 18 Years to 79 Years

Eligibility

Inclusion Criteria:

• 43 patients who had non-cardiac surgery in Seoul Paik Hospital.

Exclusion Criteria:

• have viral hepatitis and Aspartate aminotransferase, Alanine aminotransferase > 2 time of normal level

• severe lung disease

• severe heart failure ( Ejection Fraction < 40% )

• pregnancy

Study Design

Observational Model: Case-Only, Time Perspective: Prospective

Related Conditions & MeSH terms

• Chronic Kidney Disease
• Kidney Diseases
• Renal Insufficiency, Chronic

Intervention

Other:
• The level of NGAL after pre op,post op 4hr, post op 12hr

Locations

Country	Name	City	State
n/a

Sponsors (1)

Lead Sponsor	Collaborator
Inje University

Outcome

Type	Measure	Description	Time frame	Safety issue
Primary	serum NGAL level		up to post operation 12 hours	No