Chronic Kidney Disease Clinical Trial
Official title:
Effect of a 3-month Aerobic Training Program on Endothelial Function in Mild-to-moderate CKD: a Randomized Controlled Trial
Chronic kidney disease (CKD) is a prevalent disorder and a major health concern.
Cardiovascular disease is the most prevailing and life-threatening complication observed in
patients with CKD. The diagnosis of CKD places a patient at the highest cardiovascular risk
level irrespective of the stage of renal decline. Therefore, fatal cardiovascular events are
more likely to occur than the evolution to final stages of kidney disease with the need for
dialysis. Counter intuitively, treatment of classical cardiovascular risk factors does not
affect cardiovascular prognosis in CKD, which suggests that the missing link between these
two entities has not been elucidated yet.
In the present project, the investigators focus on endothelial dysfunction in patients with
CKD. Endothelial dysfunction precedes overt atherosclerotic changes by many years. In the
absence of structural changes, endothelial dysfunction is still reversible, which offers
therapeutic perspectives to tackle the progression towards atherosclerosis in an early
stage.
The purpose of this study is to determine whether an exercise training program is effective
in ameliorating endothelial dysfunction in patients with chronic kidney disease.
n/a
Allocation: Randomized, Endpoint Classification: Efficacy Study, Intervention Model: Parallel Assignment, Masking: Single Blind (Outcomes Assessor), Primary Purpose: Prevention
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