Chronic Kidney Disease Clinical Trial
Official title:
A Prospective Observational Study to Investigate the Natural History of Bone Histomorphometry and Vascular Calcification in Dialysis-dependent Patients Before and After Renal Transplantation.
A study of the natural history of bone and mineral disease (BMD) in patients with end-stage renal disease before and after kidney transplantation
Disturbances of mineral and bone diseaeses are frequently observed in CKD patients. Renal
osteodystrophy is the term to describe the bone abnormalities. Epidemiological data showed
adynamic bone disease (ABD) is the most frequent bone disorder in CKD stage 5D diseases. Low
PTH, diabetes mellitus, malnutrition, metabolic acidosis, hypogonadism and low 1,25(OH)2D
vitamin D deficiency are known risk factors for ABD. Mounting experimental data point towards
a role of protein-bound uremic retention molecules (p-cresyl sulfate and indoxyl sulfate) in
the pathogenesis and progression of ABD. ABD is not only recognized as a risk factor for
fractures but also for arterial calcification.
The aim of the present study is (1) to investigate the role of indoxyl sulfate and p-cresyl
sulfate in the pathogenesis and progression of ABD and arterial calcification in CKD stage5
and (2) to investigate the influence of renal transplantation on bone and arterial
metabolism.
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