Chronic Kidney Disease Clinical Trial
Official title:
The Effect of Various Types of the Renin-angiotensin-aldosterone System Blockade on Proteinuria in Chronic Non-diabetic Kidney Disease: a Double-blind Cross-over Randomised Controlled Study
The main purpose of the study is to compare the effects of three different types of RAAS blockade on 24 hours proteinuria in patients with non-diabetic chronic kidney disease.
Pharmacological blockade of the renin-angiotensin-aldosterone system (RAAS) is the main
target of therapy to reduces both proteinuria and the rate of decline of the glomerular
filtration rate in non-diabetic chronic renal diseases. Despite recent progress, however,
there is still no optimal therapy that can stop the progression of these nephropathies.
Therefore, it is necessary to optimize such treatment for further improving renal outcome.
The aim of the present study was to compare the effects of three different types of RAAS
blockade: (1) mineralocorticoid receptor blocker (MRB) + angiotensin receptor antagonist
(ARA); (2) direct renin inhibitor (DRI) + ARA and (3) double maximal dose of ARA on 24 hours
proteinuria in patients with non-diabetic chronic kidney disease
;
Allocation: Randomized, Endpoint Classification: Safety/Efficacy Study, Intervention Model: Crossover Assignment, Masking: Double Blind (Subject, Investigator), Primary Purpose: Treatment
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