Chronic Kidney Disease Clinical Trial
Official title:
A Randomized, Double-blind, Placebo-controlled Study to Evaluate the Safety, Tolerability and Hemodynamics of Ascending Repeated Oral Doses of SAR407899A in Patients With Moderate Chronic Kidney Disease on Stable Angiotensin Converting Enzyme-inhibitor (ACE-I) Treatment
Primary Objective:
- To assess the tolerability and safety of repeated oral ascending doses of SAR407899A in
patients with moderate chronic kidney disease (CKD) on stable angiotensin converting
enzyme-inhibitor (ACE-I)
Secondary Objectives:
- To assess in patients with moderate CKD the effect of concomitant multiple dose of
SAR407899A and ACE-Is on office and 24-hr ambulatory blood pressure and heart rate
- The effect of repeated multiple doses of SAR407899A on the pharmacodynamic response to
ACE-Is (AcSDKP)
- The pharmacokinetic profile of repeated oral administration of SAR407899A during
co-administration of ACE-Is
The total duration for this study will be around 8 weeks. ;
Allocation: Randomized, Endpoint Classification: Safety Study, Intervention Model: Parallel Assignment, Masking: Double Blind (Subject, Investigator), Primary Purpose: Treatment
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