Vitamin D Repletion in Chronic Kidney Disease

Status Completed

Clinical Trial Summary

The reason for doing this research is that people with kidney disease often suffer from heart disease. Why this happens is not fully known. A possible cause may be high blood levels of a substance made by bacteria called "endotoxin". The blood levels of this substance are high in people with medium-level kidney disease.

We want to know if replacing normal amounts of Vitamin D can help lower the levels of this substance. We also want to know if replacing normal amounts of Vitamin D is associated with other changes that may help heart disease. We hope that our research will help figure out if levels of this substance can be lowered by replacing normal amounts of Vitamin D. Normal subjects are enrolled to have a 'control' set for comparison purposes.

Clinical Trial Description

Your participation in this study requires:

- 4 visits to the outpatient clinic (including 1 screening visit)

- Providing a blood sample (less than 5 tablespoons) and a urine sample at each visit

- Taking a test to measure how leaky your gut is. This test requires that you drink a small amount of liquid (about 4 ounces) and then collect your urine for 6 hours after drinking the liquid. ;

Study Design

Endpoint Classification: Efficacy Study, Intervention Model: Single Group Assignment, Masking: Open Label, Primary Purpose: Treatment

Related Conditions & MeSH terms

Clinical Trial Details

NCT number	NCT00772772
Study type	Interventional
Source	Rockefeller University
Contact
Status	Completed
Phase	Phase 0
Start date	March 2008
Completion date	October 2009

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