Contrast-induced Nephropathy Clinical Trial
Official title:
Renoprotective Effect of Febuxostat on Contrast Induced Acute Kidney Injury in Chronic Kidney Disease Patients Stage 3
This study will determine the renoprotective effect of febuxostat in prevention of contrast induced acute kidney injury in chronic kidney disease patients Stage 3 undergoing percutaneous coronary intervention.
In this randomised non blinded clinical trial, Investigators will study 120 CKD patients undergoing PCI to determine the renoprotective effect of febuxostat in prevention of contrast induced acute kidney injury . So, the patients will be divided into two arms based on block randomization. Each arm compromise 60 patients. The first arm will receive IV hydration and N-acetylcysteine (ctrl arm) . The second arm will receive IV hydration, N-acetylcysteine and Febuxostat (F arm). Block randomization will be used in this clinical trial design to reduce bias and achieve balance in the allocation of participants to treatment arms. ;
| Status | Clinical Trial | Phase | |
|---|---|---|---|
| Terminated |
NCT04877847 -
Multi-Center Trial Utilizing Low Frequency Ultrasound in the Prevention of Post-Contrast Acute Kidney Injury
|
N/A | |
| Recruiting |
NCT02088502 -
Theophylline, N-acetylcysteine, and Theophylline Plus N-acetylcysteine in Preventing Contrast-induced Nephropathy
|
Phase 2/Phase 3 | |
| Completed |
NCT03329443 -
The Effect of Spironolactone on Acute Kidney Injury in Patients Undergoing Coronary Angiography
|
Phase 2 | |
| Recruiting |
NCT04864847 -
Clinical Validation of the RENISCHEM L-FABP POC Assay
|
||
| Completed |
NCT03627130 -
The Use of Inorganic Nitrate for the Prevention of Contrast-induced Nephropathy
|
Phase 2 | |
| Active, not recruiting |
NCT03736018 -
Randomised Controlled Trial to Assess Whether Computed Tomography Cardiac Angiography Can Improve Invasive Coronary Angiography in Bypass Surgery Patients
|
N/A | |
| Withdrawn |
NCT04598516 -
Maastricht Investigation of Renal Function in Absence of- and Post- Contrast in Patients With eGFR LEss Than 30
|
||
| Withdrawn |
NCT04603261 -
Time to Excretion of Contrast, a Maastricht Prospective Observational Study
|
||
| Recruiting |
NCT03755700 -
Vitamin E and N-acetylcysteine for Preventing Contrast-Induced Acute Kidney Injury After Coronary Artery Catheterization
|
Phase 3 | |
| Active, not recruiting |
NCT04606056 -
Risk of Acute Kidney Injury After Intravenous Contrast Computed Tomography Scans
|
||
| Terminated |
NCT02440646 -
Natural History of Coronary Atherosclerosis in Real-World Stable Chest Pain Patients Underwent Computed Tomography Angiography in Comparison With Invasive Multimodality Imaging
|
||
| Completed |
NCT00175227 -
Prevention of Contrast-Induced Nephropathy
|
N/A | |
| Completed |
NCT04014153 -
CI-AKI in Patients With Stable CAD and Comorbidities. Are we Doing Better?
|
||
| Withdrawn |
NCT04597892 -
Efficacy of Point-Of-Care Creatinine Assays in Patients With eGFR <30 Receiving Intravascular Contrast
|
||
| Completed |
NCT03305874 -
Automated Prediction and Prevention of Contrast Induced Nephropathy After Cardiac Catheterization
|
||
| Not yet recruiting |
NCT01871792 -
Preventive Effect of Pitavastatin on Contrast-Induced Nephropathy in Patients With Renal Dysfunction
|
Phase 4 | |
| Not yet recruiting |
NCT06429345 -
Coenzyme Q10 Role in Prevention of Contrast Induced Nephropathy in Acute Coronary Syndrome Patients.
|
Phase 4 | |
| Recruiting |
NCT05271448 -
Continuing or Discontinuing ACE/ARBs in Patients With Chronic Kidney Disease Undergoing Coronary Angiography
|
N/A | |
| Withdrawn |
NCT03806725 -
Safety of Iodinated Contrast in Liver Transplant Candidates With Decreased Renal Function Undergoing Coronary CT Angiography
|
||
| Completed |
NCT04163250 -
Use of Urinary Cell-Cycle Arrest Biomarkers in Contrast-Associated Nephropathy After Coronary Angiography
|