Chronic Kidney Disease Stage 5 Clinical Trial
Official title:
The Effect of an Intra-dialytic Aerobic Exercise Intervention on Vascular Function in People Undergoing Maintenance Haemodialysis Therapy for Chronic Kidney Disease Stage 5. An Exploratory Study
The aim of this study is to evaluate whether a three month intra-dialytic exercise programme improves arterial function.
Status | Recruiting |
Enrollment | 50 |
Est. completion date | February 2014 |
Est. primary completion date | July 2013 |
Accepts healthy volunteers | No |
Gender | Both |
Age group | 18 Years and older |
Eligibility |
Inclusion Criteria: - Stage 5 CKD patients (GFR <15 mL/min) receiving maintenance haemodialysis therapy - Male or female - Aged >18 years - Written informed consent Exclusion Criteria: - Pregnancy - Unstable cardiovascular conditions - Recent cerebrovascular event - Excess inter-dialytic weight gain - Use of corticosteroids, anabolic therapies, - Co-morbid catabolic conditions - Serum potassium regularly >6mmol/L - Recent pulmonary thromboembolism - Psychiatric illness including anxiety, mood and untreated eating disorders - Infection or course of antibiotics within one month of study period. - Dementia or severe cognitive impairment. |
Allocation: Randomized, Endpoint Classification: Efficacy Study, Intervention Model: Parallel Assignment, Masking: Open Label, Primary Purpose: Treatment
Country | Name | City | State |
---|---|---|---|
United Kingdom | Monklands Hospital | Airdrie |
Lead Sponsor | Collaborator |
---|---|
Queen Margaret University | British Kidney Patients Association |
United Kingdom,
Type | Measure | Description | Time frame | Safety issue |
---|---|---|---|---|
Primary | Brachial artery flow mediated dilatation | Brachial artery diameter is measured using vascular ultrasound. A cuff similar to that used for blood pressure is then inflated around the forearm for 5 minutes. Following cuff release vascular ultrasound is used to measure arterial dilation in response to reactive hyperaemia. Relative change in diameter provides a measure of endothelial function. Images are recorded over a period of 4-5 minutes post cuff release. | Baseline and 12 week follow-up | No |
Secondary | Aortic pulse wave velocity | Aortic pulse wave velocity is measured using a Vicorder (Skidmore Medical, Bristol UK). Briefly the Vicorder measures the time taken for a pulse wave to travel between a pressure cuff located on the carotid artery and another at the site of the femoral artery. The calculated velocity of the pulse wave is a measure of central arterial stiffness. | Baseline and three month follow-up | No |
Secondary | Maximal aerobic power | Peak aerobic power is assessed using a graded exercise test with respiratory gas analysis. An Astrand protocol will be used with cycle ergometry. Participants continue until volitional exhaustion or the test is terminated by the investigator. An oxygen uptake figure in ml/kg/min is a measure of peak aerobic power (VO2peak) | Baseline and three months | No |
Secondary | Timed up-and-go | The time taken to stand up from a chair, walk three metres and return is recorded. This is a functional measure of mobility with a threshold time related to falls and fractures. | Baseline and three month follow-up | No |
Secondary | Sit-to-stand 5 | The time taken to stand up from a chair five times without using upper limb assistance is recorded. This is a surrogate measure of lower limb power with a threshold that is related to balance and risk of falls. | Baseline and 3 month follow-up | No |
Secondary | Non exercise questionnaire | A non-exercise questionnaire utilising anthropometry, gender and self reported physical activity will be used to estimate aerobic fitness. This method carries minimal burden compared to physical performance tests and is a useful screening tool for health counselling. | Baseline and 3 month follow-up | No |
Secondary | Physical activity | Physical activity over a seven day period will be measured using an Actigraph accelerometer. The monitor measures body movement as activity counts which may be categorised according to level of intensity using established cut-points. | Baseline and 3 month follow-up | No |
Secondary | Kidney Disease Quality of Life Short Form (KDQOL) | The KDQOL is a self-administered questionnaire designed to measure generic health related quality life as well as condition specific items. Higher scores indicate better quality of life. | Baseline and 3 month follow-up | No |
Secondary | Duke Activity Status Index | This self administered 12 item questionnaire provides a self reported measure of physical capacity. Higher scores indicate higher fitness and ability to perform activities of daily living. | Baseline and 3 months | No |
Secondary | Leicester Uraemic Symptom Scale (LUSS) | The LUSS provides a measure of condition related symptom burden. it records the number of symptoms, frequency and their level of intrusiveness. | Baseline and 3 month follow-up | No |
Status | Clinical Trial | Phase | |
---|---|---|---|
Terminated |
NCT03539861 -
Immunomodulatory Biomimetic Device to Treat Myocardial Stunning in End-stage Renal Disease Patients
|
N/A | |
Recruiting |
NCT03311321 -
Vitamin K to Slow Progression of Cardiovascular Disease Risk in Hemodialysis Patients
|
N/A | |
Completed |
NCT05630729 -
Living With CKD: An E-Learning Platform for Adolescents With CKD About the Disease and Its Management
|
N/A | |
Withdrawn |
NCT03998917 -
Pathophysiological Characterization of the Neuromuscular Function of a Population With Multiple Comorbidities Suffering From Chronic Renal Failure in Pre-dialysis.
|
||
Recruiting |
NCT05489120 -
Low-Protein Diet With Low-Protein Foods Versus a LPD Without LP Foods in Patients With Chronic Kidney Disease (CKD)
|
N/A | |
Completed |
NCT04207203 -
Healthy Diet Rich in Potassium to Chronic Kidney Disease With Sodium Zirconium Cyclosilicate: A Feasibility Study
|
N/A | |
Not yet recruiting |
NCT04608422 -
Bioeletric Stimulation in Patients With Chronic Kidney Failure
|
N/A | |
Completed |
NCT03868371 -
Acute Changes in the Mineral Metabolism After a High Phosphorous Containing Meal in Dialysis Patients
|
N/A | |
Active, not recruiting |
NCT05225454 -
The Life Style Patterns and the Development Trend of Chronic Diseases in Healthy and Sub-healthy Groups Were Analyzed by Using Data-mining Techniques
|
||
Completed |
NCT03459807 -
Blood Pressure Lowering in Dialysis (BOLD) Trial
|
Phase 2 | |
Not yet recruiting |
NCT03005847 -
The Effect of Fermented Papaya Preparation on Patients With Chronic Kidney Disease Under Dialysis Receiving Intravenous Iron
|
N/A | |
Recruiting |
NCT05726526 -
CKD Specific Telemonitoring Platform to Minimize Adverse Outcomes in High Risk CKD Patients
|
N/A | |
Recruiting |
NCT04330807 -
Physiopathology of Neuromuscular Function Related to Fatigue in Chronic Renal Disease
|
N/A | |
Active, not recruiting |
NCT02858778 -
Timing of Acute Palliative Care Consultation in Critically Ill Patients
|
N/A | |
Active, not recruiting |
NCT04034966 -
Utility of Telemedicine in the Follow-Up of Patients in Peritoneal Dialysis
|
N/A | |
Completed |
NCT04012957 -
Desidustat in the Treatment of Anemia in CKD
|
Phase 3 | |
Terminated |
NCT02039167 -
Left Atrial Appendage Occlusion vs. Usual Care in Patients With Atrial Fibrillation and Severe Chronic Kidney Disease
|
N/A | |
Completed |
NCT01764854 -
Pharmacodynamic Study of AZD1722 in End-stage Renal Disease Patients on Hemodialysis
|
Phase 2 | |
Active, not recruiting |
NCT06037265 -
PR-0164 First in Human Clinical Trial of the PAVmed PortIO Intraosseous Infusion System
|
N/A | |
Active, not recruiting |
NCT05350098 -
Efficacy of Plant-protein Diets in Patients With Chronic Kidney Disease
|
N/A |