Chronic Kidney Disease (CKD) Clinical Trial
Official title:
The Impact of Vitamin D Supplementation on Vascular Stiffness and Blood Pressure in Chronic Kidney Disease Patients
Individuals with kidney disease have a high risk of heart disease. This is not related to traditional risk factors, such as high blood pressure, high cholesterol or being overweight. A lack of vitamin D could be the reason why blood vessels become damaged and could explain the link between heart disease and kidney disease.
Most people living in Canada do not receive enough vitamin D from the sun or from the food
they eat. When a person has kidney disease this is a particular problem as kidney disease
stops what little vitamin D we do have being activated in the body. Low levels of activated
vitamin D causes a domino effect with calcium and phosphate and all the hormones that
control calcium and phosphate. Some people believe that this imbalance damages the blood
vessels causing them to become stiff and inflexible (arterial stiffness) and this in turn
could cause heart disease. In addition there are two different types of vitamin D that can
be prescribed and it is currently not known whether there is any difference between the two
types of vitamin D and the effect they have on the blood vessels.
The purpose of this study is to investigate whether providing vitamin D as a medication can
have a direct affect on the stiffness of the blood vessels. The findings of this study will
help both physicians and dietitians decide whether Vitamin D therapy is beneficial to
patients and should help decide which type of Vitamin D is best to give to people with
chronic kidney disease (CKD).
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