Chronic Insomnia Clinical Trial
Official title:
Effects of Chronic Insomnia on the Neuroendocrine Regulation of Glucose and Lipid Metabolism
We aim to assess the influence of chronic insomnia on the neuroendocrine regulation of the glucose and lipid metabolism to more clearly define the metabolic derangements associated with chronic insomnia and to prove that chronic insomnia is associated with increased levels of stress hormones, cytokines and impaired insulin sensitivity.
Sleep fragmentation has previously been shown to result in activation of the stress axis as
indicated by enhanced cortisol and catecholamine release and a proinflammatory state
mirrored by increased concentrations of proinflammatory cytokines such as IL-6 and TNFa.
Therefore sleep deprivation is associated with a similar pattern of endocrine and
proinflammatory alterations that may promote the insulin resistant state. Thus, it is of
paramount interest to clearly define the metabolic alterations in patients with primary
insomnia.
Patients with with suspected primary insomnia will be recruited from the sleep clinic at the
University Hospital Basel and by newspaper ads. Primary insomnia will be diagnosed by a
polysomnographic study and the exclusion of secondary causes such as depression, sleep apnea
and restless legs syndrome. Eligible patients will be admitted to the CRC for metabolic
studies, including baseline blood samples for the measurement of hormones, cytokines and
adipokines, a euglycemic-hyperinsulinemic clamp study for the assessment of glucose turnover
and insulin sensitivity and in vivo NMR studies to determine intrahepatic and
intramyocellular lipid content.
The data obtained in insomnic patients will be compared to those of a control group matched
for age, sex, BMI, menopausal status and physical activity selected from the general
population.
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Observational Model: Case Control, Time Perspective: Prospective
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