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Chronic Insomnia clinical trials

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NCT ID: NCT02048878 Completed - Chronic Insomnia Clinical Trials

Hyper-Arousal in Chronic Primary Insomnia

Start date: January 2014
Phase:
Study type: Observational

The purpose of this study is to determine whether individuals with chronic insomnia disorder have a higher degree of physiologic arousal (resulting in their trouble sleeping) than good sleepers. The primary goal is to perform a rigorous quantitative assessment of physiologic hyper-arousal across two domains (autonomic nervous system and neurophysiology) in patients with chronic primary insomnia as compared to good sleepers matched for sex, age, body mass index (BMI) and race/ethnicity.

NCT ID: NCT01995838 Completed - Elderly Clinical Trials

A Multicenter, Randomized, Double-blind, Placebo-controlled, Parallel-group, Bayesian Adaptive Randomization Design, Dose Response Study of the Efficacy of E2006 in Adults and Elderly Subjects With Chronic Insomnia

Start date: November 13, 2013
Phase: Phase 2
Study type: Interventional

This is a multicenter, multiple dose, randomized, double-blind, placebo-controlled, parallel-group, Bayesian adaptive, dose response study in subjects with chronic insomnia. Subjects will be randomized to 1 of 6 doses of E2006 (1 mg, 2.5 mg, 5 mg, 10 mg, 15 mg, or 25 mg) or placebo.

NCT ID: NCT01949389 Completed - Chronic Insomnia Clinical Trials

Piloting an Internet-based Therapy for Insomnia in a Population of Veterans With Substance Use Disorders

Start date: October 2012
Phase: N/A
Study type: Interventional

The purposes of this study is to examine the feasibility of implementing an internet-based treatment for insomnia among veterans with substance use disorders, some with co-morbid serious mental illness, and to develop potential methods to support and encourage veterans while they self-administer this treatment. Our hypotheses are that the implementation of an internet-based therapy will be feasible and that a method of support can be devised, and tested in the future.

NCT ID: NCT01286324 Completed - Chronic Insomnia Clinical Trials

Chamomile for Chronic Primary Insomnia

Start date: July 2008
Phase: Phase 2
Study type: Interventional

The purpose of this study is to determine if an herb called chamomile can help to treat insomnia (difficulty in going to sleep or getting enough sleep) by increasing the amount of time that you sleep and/or improving the quality of your sleep. The study will also be looking at the effect of chamomile on day time fatigue and functioning.

NCT ID: NCT00915135 Completed - Chronic Insomnia Clinical Trials

Efficacy and Safety of Ramelteon on Chronic Insomnia

Start date: May 2002
Phase: Phase 2
Study type: Interventional

The purpose of this study is to determine the dose response of Ramelteon, once daily (QD), in Japanese subjects with Chronic Insomnia

NCT ID: NCT00869934 Completed - Chronic Insomnia Clinical Trials

Cognitive-Behavior Therapy for Insomnia

Start date: April 2008
Phase: Phase 4
Study type: Interventional

Insomnia is a prevalent public health problem affecting large segments of the population on an occasional, recurrent, or chronic basis. Persistent insomnia is associated with impairments in daytime functioning, reduced quality of life, and increased health-care costs. Despite evidence that cognitive-behavior therapy (CBT) is an effective and well accepted treatment for insomnia, a significant proportion of individuals do not respond adequately to this treatment. Hence, there is a need to identify the active therapy components and mechanisms of change in order to develop more effective therapeutic approaches and optimize outcomes. The specific aims of the proposed study are to (a) evaluate the effects of behavioral versus cognitive therapies for insomnia and associated daytime impairment, (b) investigate the mechanisms of change and, (c) examine the impact of insomnia therapies on psychiatric conditions commonly associated with insomnia (anxiety disorders and depression). A sample of 186 adults with chronic insomnia will be recruited from two sites (Laval University and University of California, Berkeley). Participants will be randomly assigned to one of three groups: (a) behavior therapy (BT; n = 62), (b) cognitive therapy (CT; n = 62), or (c) cognitive-behavior therapy (CBT; n = 62). Measures of outcome (sleep/insomnia, daytime functioning) will be administered at baseline, end of treatment, and at 6- and 12-month follow up. Measures of mechanisms of change (maladaptive sleep habits, unhelpful beliefs, sleep-related worry) will be administered at baseline, after the 4th and 8th therapy sessions, and at the end of treatment. It is expected that (1) BT and CBT will be more effective for improving sleep, relative to CT, (2) CT and CBT will be more effective for reducing daytime functional impairment, relative to BT and (3)CT will be more effective than BT in reducing comorbid psychiatric disorders. The public health significance of the proposed study is that it will provide useful information to improve our understanding of insomnia and to enhance efficacy and efficiency of therapeutic approaches for a prevalent and costly health problem. The long-term objective is to contribute to the development and dissemination of evidence-based treatments for chronic insomnia and its common comorbidities.

NCT ID: NCT00840255 Completed - Chronic Insomnia Clinical Trials

Brief Behavioral Treatment of Insomnia in Military Veterans: Phase 2 (BBTIMVII)

BBTIMVII
Start date: April 2009
Phase: N/A
Study type: Interventional

The purpose of this study is to adapt and test the effects of a 4-week behavioral treatment that targets chronic insomnia (lasting >1 month) in service members returning from Operation Iraqi Freedom (OIF) and Operation Enduring Freedom (OEF), finalizing a treatment manual.

NCT ID: NCT00679406 Completed - Chronic Insomnia Clinical Trials

Brief Behavioral Treatment of Insomnia in Military Veterans: Phase 1

BBTIMV1
Start date: June 2008
Phase: N/A
Study type: Interventional

The purpose of this study is to adapt and test the effects of a 4-week behavioral treatment that targets chronic insomnia (lasting >1 month) in service members returning from Operation Iraqi Freedom (OIF) and Operation Enduring Freedom (OEF).

NCT ID: NCT00671567 Completed - Chronic Insomnia Clinical Trials

Ramelteon in Adults With Chronic Insomnia

Start date: December 2002
Phase: Phase 3
Study type: Interventional

The purpose of this study is to determine the safety and efficacy of Ramelteon, once daily (QD), in adult subjects with chronic insomnia.

NCT ID: NCT00671294 Completed - Chronic Insomnia Clinical Trials

Safety and Efficacy of Ramelteon in Elderly Subjects With Chronic Insomnia.

Start date: October 2002
Phase: Phase 3
Study type: Interventional

This purpose of this study is to assess the efficacy and safety of Ramelteon, once daily (QD), in elderly subjects with chronic insomnia.