Chronic Hand Dermatitis Clinical Trial
Official title:
A 4-Week Randomized, Double-Blind, Placebo-Controlled, Right-Left Comparison Study With E-DO in Chronic Hand Dermatitis
The objective of this study is to evaluate the topical E-DO in patients with Chronic Hand Dermatitis (fu kuei shou).
Hand dermatitis, also called fu kuei shou, is a skin condition in which the hands develop a
rash and become red, dry, cracked, and inflamed. This is a very common occuring in about 10%
of women and 4% of men. The condition can eventually cause pain on contact with even simple
solutions such as water. Hand dermatitis is particularly common in industries involving
cleaning, catering, metalwork, hairdressing, healthcare and mechanical work, and is often
difficult to be treated effectively. Some patients develop varying levels of disability due
to lack of acceptable effective treatments and may be forced to change occupations in order
to achieve relief.
Primary treatment for hand dermatitis is typically topical corticosteroids, especially when
the offending agent(s) cannot be identified or avoided. However, patients may eventually
develop tachyphylaxis to the anti-inflammatory activity of mid-potency or high-potency
topical corticosteroids and patients with severe, chronic involvement may often be less
likely to respond. Potential topical alternatives to corticosteroids include psoralen plus
ultraviolet (PUVA), but the phototherapies are inconvenient because multiple clinical visits
are required and hand phototherapy units may not be available.
Moisturizers have been found to help restore the skin barrier providing a protective layer
on surface of the skin to trap water and prevent the penetration of irritants and allergens.
An emollient cream is superior in trapping the moisture within the skin. Emollients may form
a covering film, which acts as a barrier for chemicals from the exterior and which restricts
the loss of water and other essential substances from the interior. E-DO gel is a potential
agent for revitalizing our skin cells so that regain their moisture retention capacity.
E-DO has known significant improvements in wound healing and the inhibition of
Staphylococcus aureus and Propionibacterium acnes. This pilot research trial will
investigate the effect of topical E-DO for patients with hand dermatitis.
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Allocation: Randomized, Endpoint Classification: Safety/Efficacy Study, Intervention Model: Parallel Assignment, Masking: Double Blind (Subject, Caregiver, Investigator, Outcomes Assessor), Primary Purpose: Treatment
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