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Clinical Trial Summary

Identify the cause of chronic allograft dysfunction using a combination of comprehensive clinical and histologic information in Chinese renal transplant recipients, then to identify the position of CNI nephrotoxicity in CAD.Chronic allograft dysfunction reflects the dual impact of both immunologic and nonimmunologic (primarily calcineurin inhibitor [CNI]nephrotoxicity) injury. In previous, CNI nephrotoxicity is overstated and considered one of the major causes of CAD, however, recently there has been found most death-censored graft losses to be the result of alloimmune or autoimmune injury, with only a minority of cases attributable to CNI toxicity. Unfortunately, Situation of objective CNI toxicity in CAD in China is not well analyzed. To improve perception of Neo safety with more local evidence, we want to do a retrospective study to identify the cause of chronic allograft dysfunction using a combination of comprehensive clinical and histologic information in Chinese renal transplantation recipients.


Clinical Trial Description

n/a


Study Design

Time Perspective: Retrospective


Related Conditions & MeSH terms


NCT number NCT01794871
Study type Observational
Source Shanghai Zhongshan Hospital
Contact Tongyu Zhu
Phone +8613816002121
Email tyzhu@fudan.edu.cn
Status Recruiting
Phase N/A
Start date May 2012
Completion date August 2013

See also
  Status Clinical Trial Phase
Withdrawn NCT00878761 - Study of STX-100 in Renal Transplant Patients With Interstitial Fibrosis and Tubular Atrophy (IF/TA) Phase 2