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Chromosome Aberrations clinical trials

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NCT ID: NCT04935138 Terminated - Clinical trials for Early Pregnancy Loss

Cell-free DNA Analysis of Chromosome Anomalies in Early Pregnancy Loss

Start date: June 1, 2021
Phase:
Study type: Observational

The study assesses the accuracy of cell-free DNA (cfDNA) analysis in detecting whole chromosomal aneuploidies from maternal plasma of patients with early, missed miscarriage.

NCT ID: NCT01463410 Terminated - Clinical trials for Acute Myeloid Leukemia (AML)

Accuracy Testing of the Chromosomal Aberration and Gene Mutation Markers of the AMLProfiler

Start date: October 2011
Phase: N/A
Study type: Observational

This clinical study will demonstrate the accuracy of the chromosomal aberration and gene mutation markers of the AMLProfiler molecular diagnostic assay and generate clinical performance data to support a Pre-Market Approval (PMA) submission to the Food and Drug Administration for in vitro diagnostic use within the United States of America. The objective is to demonstrate the positive and negative percent agreement of each marker by comparing AMLProfiler results from multiple clinical participating sites with data generated using a laboratory developed bi-directional sequencing method generated at the molecular diagnostic reference lab. The AMLProfiler assay is a qualitative in vitro diagnostic test for the detection of AML or APL specific chromosomal aberrations (specific recurrent translocations and inversions), as well as expression of specific genetic markers in RNA extracted from bone marrow aspirates of patients with Acute Myeloid Leukemia.

NCT ID: NCT00691574 Terminated - Clinical trials for Chromosome Disorders

Melatonin Levels in Smith Magenis Syndrome (SMS)

Start date: September 1998
Phase: N/A
Study type: Interventional

The goal of this pilot project is to determine whether melatonin levels are disordered in patients with Smith-Magenis Syndrome (SMS) and whether melatonin treatment can correct abnormal circadian rhythms in SMS patients. In addition, the study investigates the effects of bright light in an elderly control population that exhibits low melatonin secretion.

NCT ID: NCT00461929 Terminated - Clinical trials for Chronic Myeloid Leukemia

Chromosome Abnormalities in Chronic Myeloid Leukemia (CML) on Imatinib. GIST Patients on Imatinib

GIST
Start date: February 2005
Phase: Phase 4
Study type: Interventional

In order to distinguish between clonal instability driven by imatinib in CML and actual changes with secondary clones induced by imatinib we would like to investigate the karyotype of non-CML patients treated with imatinib such as GIST patients.