Choroidal Neovascularization Clinical Trial
Official title:
Biomarkers Analysis of Mineralocortoid Receptor Activation in the Serum and Ocular Fluid of Patients With Choroidal Neovascularization
The aim of the study is to find biomarkers in the blood and aqueous humor of patients with type 1 choroidal neovascularization and correlate them with the response to anti-VEGF treatment.
Age-related macular degeneration (AMD) is the most frequent cause of blindness in
industrialized countries. Multiple molecular pathways have been implicated in the
pathogenesis of choroidal neovascularization (CNV). Currently, the treatment relies on
neutralization of VEGF (Vascular Endothelial Growth Factor). However some patients have an
incomplete response to anti-VEGF treatment. A recent study suggested the implication of the
mineralocorticoid receptor pathway in the formation of CNV.
The study (of investigators) aim is to evaluate the concentation of metabolites of MR pathway
in the blood and aqueous humor of patients with CNV and compared them with patients without
CNV in order to increase our understanding of CNV pathogenesis and find potential biomarker
of response to anti-VEGF treatment.
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