Clinical Trial Details
— Status: Recruiting
Administrative data
NCT number |
NCT05921643 |
Other study ID # |
GLASS-BONA |
Secondary ID |
|
Status |
Recruiting |
Phase |
|
First received |
|
Last updated |
|
Start date |
September 29, 2023 |
Est. completion date |
April 2026 |
Study information
Verified date |
March 2024 |
Source |
Centre Hospitalier Intercommunal Creteil |
Contact |
Maxime fieux |
Phone |
04.72.66.64.15 |
Email |
maxime.fieux[@]chu-lyon.fr |
Is FDA regulated |
No |
Health authority |
|
Study type |
Observational
|
Clinical Trial Summary
Adult patients referred to the ENT surgery department of the Hospices Civils de Lyon with
cholesteatoma that had never been operated on.
All patients will benefit from surgical management for cholesteatoma initially in the
operating room under general anesthesia. The surgical technique (closed technique) is the
reference technique for the management of cholesteatoma in adults. It involves a
cartilaginous removal to reconstruct the attical region. Then a filling material is used to
fill the mastoid (GlassBONE™ or Bonalive™), and above all to stabilize the cartilaginous
fragment to prevent a recurrence.
Description:
Patients are operated on as an outpatient and receive a phone call the next morning to look
for an initial complication. The patients will be reviewed in consultation at D8, D45, 3
months, 6 months and at 18 months with clinical examination (otoscopy) and audiometry at each
consultation. The consultation on D8 is used for removal of the expandable cotton put in
place in the external auditory canal (CAE) during surgery to guide healing, control
post-auricular healing and look for signs of complication during the examination. A cone beam
(CBCT) is performed during the consultation on D45 to confirm the correct position of the
ossiculoplasty and check the persistence of the initial filling. The proportion of filled
mastoid at D45 will serve as a reference to then be compared to the CT scan at 6 months and
at 18 months. During surgery, and at the consultation at 6 months and 18 months, patients
will also have to complete a quality of life questionnaire (Chronic Ear Survey French
version; in the Appendix).