Cholelithiasis Clinical Trial
Official title:
Granisetron Effect on Hemodynamic Changes and Intubation Condition During Anesthesia Induction in Laparoscopic Cholecystectomy
Propofol is one of the most commonly used anesthetic agents because of its ability to induce
rapid and reliable collection. However, hypotension and injection pain in the induction are
the most common complications. After induction of propofol; The cardiovascular system
depresses, resulting in a drop in blood pressure due to decreased cardiac output and systemic
vascular resistance. This may also contribute to the reduction of sympathetic tone activity
in the central way, and slight reduction in the number of pulses that develop as a result of
increasing vagal activity. İn order to attenuate these hemodynamic undesired effects caused
by propofol, various agents were tried such as atropine, ephedrine, volume replacement ringer
lactate, ketamine. Ondansetron and granisetron, which are used for postoperative nausea and
vomiting prophylaxis, have been used as such. Therefore, ondansetron and granisetron were
preventing hypotension induced by post-spinal and general anesthesia induction.
The investigator also tried to demonstrate the effect of granisetron, another serotonin type
3 (5-HT3) receptor antagonist for postoperative nausea and vomiting prophylaxis, on induction
hypotension and intubation quality after propofol induction in this study
150 participants with American Society of Anesthesiologists (ASA) physical score I-II who
underwent elective laparoscopic cholecystectomy between the ages of 18-70 will be enrolled.
Participants will be divided into two groups using granisetron and control.
All participants will be premedicated with 0.05 mg kg-1 midazolam 30 minutes before the
operation. ASA, age, sex, weight demographic data of the participants who were taken to the
operating room will record. Peripheral oxygen saturation (SPO2), noninvasive blood pressure
and electrocardiography (ECG) will monitored. A venous cannula will place on the back of the
hand. Participants will randomly divide into 2 groups by closed envelope method.
Five minutes before the induction of group G, 1 ml (1 mg / ml) iv granisetron, group K will
receive 1 ml saline. Propofol at induction will be administered at a dose of 0.6 mg / kg of
rocuronium at a dose of 2 mg / kg. Pre-induction, post-intubation and every five minutes
SPO2, diastolic arterial pressure (DAP), mean arterial pressure (MAP), systolic arterial
pressure(SAP) and heart rate (HR) will record. Intubation quality will be evaluated by evans
score.
Systolic Blood Pressure <Control + 15 0 <Control + 30 1 1
- Control + 30 2 Heart Rate Pressure <Control + 15 0 <Control + 30 1
- Control + 30 2 Sweating No 0 Moist leather 1 Visible sweating 2 Tears No 0 Yes 1
Overflowing 2
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