Ondansetron Effect on Pain Relief After Laparoscopic Cholecystectomy

Status Completed

Clinical Trial Summary

Laparoscopic cholecystectomy (LC) is an easy procedure characterized by its minimal invasiveness, less post-operative pain and early recovery when compared to the open conventional cholecystectomy. However, patients who have undergone LC still complain of postoperative pain. It has been reported that ondansetron produces numbness when injected under the skin and has local anesthetic effect that is 15 times more potent than lidocaine the most widely used local anesthetic and probably explains its antiemetic action. It possesses anti-inflammatory, anesthetic, and analgesic properties by its multifaceted actions as a 5-HT3 receptor antagonist, a Na channel blocker, and a mu-opioid agonist which may have a potential role in decreasing pain. The study aimed to demonstrate the effectiveness of IP administration of ondansetron on pain management post LC.

Clinical Trial Description

n/a

Study Design

Related Conditions & MeSH terms

Cholecystitis

Clinical Trial Details

NCT number	NCT04468685
Study type	Interventional
Source	National Hepatology & Tropical Medicine Research Institute
Contact
Status	Completed
Phase	Phase 2
Start date	July 15, 2020
Completion date	December 18, 2020

View Details

See also
Status	Clinical Trial	Phase
Not yet recruiting	`NCT03636841` - Reduction of Operating Time by a Smoke Electroprecipitation Device for Acute Cholecystitis	N/A
Completed	`NCT02379780` - Ultrasound Guided Subcostal Transversus Abdominis Plane Versus Paravertebral Block in the Laparoscopic Cholecystectomy	N/A
Completed	`NCT01937104` - ONSD According to the Position During Laparoscopy	N/A
Completed	`NCT02264444` - Establishing Visualization Grading Scale on LESS Cholecystectomy	N/A
Completed	`NCT02461147` - Prospective Validation of "Cholecystectomy First" Strategy for Gallstone Migration
Completed	`NCT01476995` - Prognostic Indicators as Provided by the EPIC ClearView	N/A
Completed	`NCT00940264` - Laparoscopic Transvaginal Hybrid Cholecystectomy: a Prospective Data Collection.	N/A
Completed	`NCT00746850` - Harmonic in Laparoscopic Cholecystectomy for Acute Cholecystitis	N/A
Completed	`NCT00370344` - Small-incision Open Cholecystectomy or Laparoscopic Cholecystectomy for Gallbladder Disease	Phase 2/Phase 3
Completed	`NCT00195351` - Study Comparing Tigecycline Versus Ceftriaxone Sodium Plus Metronidazole in Complicated Intra-abdominal Infection	Phase 4
Completed	`NCT02858986` - 3D Versus 4K Laparoscopic Cholecystectomy	N/A
Completed	`NCT04602156` - US-guided Trocar Versus Seldiger Technique for Percutaneous Cholecystostomy	N/A
Completed	`NCT04942665` - Low Dose ICG for Biliary Tract and Tumor Imaging	Phase 2
Completed	`NCT02547064` - Effect of Modified Stylet Angulation on the Intubation With GlideScope®	N/A
Completed	`NCT00230971` - Study Comparing Tigecycline Versus Ceftriaxone Sodium Plus Metronidazole in Complicated Intra-abdominal Infection (cIAI)	Phase 4
Completed	`NCT04122261` - A Clinical Study of Chinese Domestic Surgical Robot	N/A
Completed	`NCT04716166` - Incentive Spirometry and Upper Abdominal Laparoscopic Surgery	N/A
Completed	`NCT01476319` - Improving Informed Consent Process for Percutaneous Cholecystostomy in the Emergency Department	N/A
Withdrawn	`NCT02225418` - Transmuscular Quadratus Lumborum Block for Laparoscopic Cholecystectomy	N/A
Suspended	`NCT04306939` - Genomic Resources for Enhancing Available Therapies (GREAT1.0) Study