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Cholangitis, Sclerosing clinical trials

View clinical trials related to Cholangitis, Sclerosing.

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NCT ID: NCT05187312 Recruiting - Pancreatic Cancer Clinical Trials

Registry for Advanced Endoscopy

ERDB
Start date: January 14, 2022
Phase:
Study type: Observational [Patient Registry]

Observational registry including endoscopic diagnostic and therapeutic interventions in the gastrointestinal tract

NCT ID: NCT05181332 Recruiting - Cirrhosis Clinical Trials

Predictive Models of Hepatic Decompensation and Survival Outcomes in Pediatric Patients With Cirrhosis

Start date: January 1, 2021
Phase:
Study type: Observational

The aim of this study was to developed and validated models to predict hepatic decompensation and survivals in pediatric patients with cirrhosis and compared these models with currently available models.

NCT ID: NCT05082779 Completed - Clinical trials for Primary Sclerosing Cholangitis (PSC)

Study in Healthy Volunteers to Evaluate the Safety, Tolerability, Pharmacokinetics and Pharmacodynamics of CS0159

Start date: October 26, 2021
Phase: Phase 1
Study type: Interventional

The whole study includes 2 parts. Both the SAD study and MAD study are randomized, double-blinded, and placebo-controlled studies, conducted in healthy subjects, to assess the safety, tolerability, pharmacokinetics, and pharmacodynamics profiles of CS0159. The SAD part also involves a pilot food effect (FE) study, designed to assess the food effect on single-dose PK profile in healthy subjects.

NCT ID: NCT04981756 Active, not recruiting - Clinical trials for Primary Sclerosing Cholangitis

PSC Clinical Epidemiology in China

Start date: April 7, 2021
Phase:
Study type: Observational

Primary sclerosing cholangitis (PSC) is a rare disease but is increasingly reported in China (mainly in the Chinese language). However, most of the PSC literatures reported from China are case reports, small case series, and review articles. Up to now, there is no information on the epidemiology and disease burden of PSC in China. This study would use EMR/HIS and research databases to investigate the epidemiology, cascade, and treatment pattern of PSC in China.

NCT ID: NCT04753996 Recruiting - Cholangiocarcinoma Clinical Trials

Characterization of Biliary Cell-derived Organoids From Bile of PSC and Non-PSC Patients

Start date: March 8, 2021
Phase:
Study type: Observational

The purpose of this research is to create a collection of bile, bile duct brushings and medical information from people with Primary Sclerosing Cholangitis (PSC) and controls to learn more about changes that occur in the liver.

NCT ID: NCT04685200 Recruiting - Clinical trials for Primary Sclerosing Cholangitis

Unraveling the Mechanisms Underlying Primary Sclerosing Cholangitis Through a Multidisciplinary, Integrative Research Approach

Start date: March 31, 2023
Phase:
Study type: Observational

Background: Primary sclerosing cholangitis is a rare chronic liver disease. It affects the bile ducts of the liver. It can result in bile duct infections, cirrhosis, cancer, and end stage liver disease. Researchers want to learn more about this disease. Objective: To understand the biological causes of primary sclerosing cholangitis. Eligibility: Adults age 18 and older who have primary sclerosing cholangitis. Design: Participants will be screened with a medical history, physical exam, and blood tests. Participants will give blood, saliva, urine, and stool samples. They will have nasal swabs. They will complete surveys. Participants will get an intravenous (IV) catheter. A plastic tube is inserted into an arm vein. Participants will have a colonoscopy. A tube with a video camera at the end is inserted into the rectum. Participants will have an upper endoscopy. A scope with a light and camera at its tip is used to look inside the upper digestive tract. Participants will have a liver biopsy, entering through the chest wall or a neck vein. Blood is drawn from a blood vessel that carries blood to the liver. A liver tissue sample is taken. Participants will have magnetic resonance imaging or spectroscopy. They will get a contrast agent through an IV. Participants may have an optional bone marrow aspiration. A large needle is inserted into the hip to withdraw marrow. Participants will have a liver ultrasound. Participants will complete a 3-day food diary. They will have a nutrition assessment. Participants may give contact details for people who live with them, to also take part in this study. Participation will last for 12 months....

NCT ID: NCT04678219 Recruiting - Clinical trials for Primary Sclerosing Cholangitis

A Pilot Study Examining Diet in Primary Sclerosing Cholangitis

DINER
Start date: August 28, 2020
Phase: N/A
Study type: Interventional

This research study is exploring the effects of dietary intervention in PSC. Study participants will be randomly assigned to either the Specific Carbohydrate Diet (SCD) or a vegan/low-sulfur diet for 8 weeks; the entire study will last approximately 14 weeks. Participants will work with BWH Registered Dieticians and receive dietary educational materials, recipes, and a food procurement stipend to support the new diet. Subjects will attend 7 video visits and have regular lab tests performed, requiring blood and stool samples.

NCT ID: NCT04663308 Recruiting - Clinical trials for Primary Sclerosing Cholangitis

A Study to Evaluate Efficacy and Safety of an Investigational Drug Named Volixibat in Patients With Itching Caused by Primary Sclerosing Cholangitis (PSC)

VISTAS
Start date: December 18, 2020
Phase: Phase 2
Study type: Interventional

The purpose of this clinical research study is to learn more about the use of the study medicine, volixibat, for the treatment of pruritus (itching) associated with Primary Sclerosing Cholangitis (PSC), and to assess the possible impact on the disease progression of PSC.

NCT ID: NCT04595825 Active, not recruiting - Clinical trials for Primary Sclerosing Cholangitis

CM-101 in PSC Patients -The SPRING Study

Start date: October 1, 2020
Phase: Phase 2
Study type: Interventional

This study is designed to assess the safety, tolerability and activity of the anti-human CCL24 monoclonal antibody CM-101 in adult subjects with Primary Sclerosing Cholangitis (PSC). At least 68 subjects at approximately 50 sites will be randomized to receive either CM-101 at doses of 10 mg/kg or 20 mg/kg or matching placebo.

NCT ID: NCT04480840 Completed - Clinical trials for Primary Sclerosing Cholangitis

Phase 2a Evaluation of Safety, Tolerability, and Pharmacokinetics of PLN-74809 in Patients With Primary Sclerosing Cholangitis (PSC)

Start date: July 27, 2020
Phase: Phase 2
Study type: Interventional

A Phase 2a, multicenter, randomized, double-blind, dose-ranging, placebo-controlled, study to evaluate the safety, tolerability, and PK of PLN-74809 in participants with primary sclerosing cholangitis and suspected liver fibrosis