Standing Balance Control Across the Lifespan

Children, Adult Clinical Trial

— BaCoMech  

Official title:

Balance Control Mechanisms During Perturbed Standing Across the Lifespan

Clinical Trial Details — Status: Completed

Administrative data

• NCT number: NCT04050774
• Other study ID #: Projectlifespanbalance2018-001
• Status: Completed
• Phase: N/A
• Start date: November 21, 2018
• Est. completion date: April 1, 2021

Study information

• Verified date: August 2022
• Source: Hasselt University
• Contact: n/a
• Is FDA regulated: No
• Study type: Interventional

Clinical Trial Summary

Falls are the leading cause of nonfatal injuries in children and elderly. To understand the causes of falling in these populations, fundamental knowledge of how ageing affects balance control is of utmost importance.

In general, two biomechanical mechanisms allow people to control balance; 1.moving the center of pressure within the base of support using ankle muscle activation; 2.counter-rotating segments around the center of mass. To understand how balance is controlled differently across the lifespan, 4 age groups (each N=20) will be compared to each other; i.e. prepubertal children (6-9y), postpubertal children (15-17y), young adults (18-24y), healthy non-falling older adults (65-80y). .

A force plate platform combined with 3D movement registration will be used to determine the biomechanical balance control strategy across the lifespan during unperturbed and perturbed standing. The innovative but focused scope of this study could provide a breakthrough in our biomechanical understanding of balance control and, in particular, the changes in limitations of balance control in childhood and an ageing (fall-prone) population. The gained fundamental knowledge could lead to unprecedented insights in the causes of falling across the lifespan and in possible targets for intervention.

Recruitment information / eligibility

• Status: Completed
• Enrollment: 41
• Est. completion date: April 1, 2021
• Est. primary completion date: April 1, 2021
• Accepts healthy volunteers: Accepts Healthy Volunteers
• Gender: All
• Age group: 6 Years to 80 Years

Eligibility

Inclusion Criteria:

• prepubertal children (6-9y)

• postpubertal children (15-18y)

• young adults (18-24y)

• healthy non-falling older adults (65-80y) will be included if they 1) did not experience two or more falls during normal daily activities in the preceding year and 2) have no cognitive impairment (tested with Mini-Mental state examination).

Exclusion Criteria:

1. inability to speak and understand Dutch;

2. inability to maintain independent unsupported stance for 60 seconds;

3. current diagnosis of neurological or sensory disorders;

4. recurrent dizziness;

5. obesity ;

6. a history of orthopaedic disorders;

7. surgical operation of the lower extremity during last two years;

8. use of drugs affecting the CNS or known to affect balance control.

Related Conditions & MeSH terms

• Children, Adult

Intervention

Device:
• Balance boards
The unstable surface will be created with a balance board consisting of a wooden board mounted on a section of a cylinder, creating an unstable support in the sagittal plane or in the frontal plane. The participants will stand on three balance boards, varying the height of the surface of the board above the point of contact (15, 17 and 19 cm respectively). The radius of the cylinder will kept constant at 24 cm. The standing surface will be 48cm x 48 cm

Locations

Country	Name	City	State
Belgium	Hasselt University	Hasselt

Sponsors (2)

Lead Sponsor	Collaborator
Hasselt University	VU University of Amsterdam

Country where clinical trial is conducted

Belgium, 

Outcome

Type	Measure	Description	Time frame	Safety issue
Primary	Balance Control; centre of mass acceleration based on 3D movement registration and ground reaction forces	Centre of mass acceleration (in kg.m2/s2) (calculations based on; van Dieen JH, van Leeuwen M, Faber GS. Learning to balance on one leg: motor strategy and sensory weighting. J Neurophysiol. 2015;114(5):2967-82.)	day 1
Primary	Contribution of the ankle strategy to centre of mass acceleration based on 3D movement registration and ground reaction forces	The contribution of the ankle strategy (difference between the centre of pressure and the centre of mass (in kg.m2/s2)) to centre of mass acceleration in the sagittal and frontal plane will be calculated based on total body kinematics (SIMI motion - 3D movement registration) and kinetics (AMTI force plate) (calculations based on; van Dieen JH, van Leeuwen M, Faber GS. Learning to balance on one leg: motor strategy and sensory weighting. J Neurophysiol. 2015;114(5):2967-82.)	day 1
Primary	Contribution of the counter-rotation mechanism to centre of mass acceleration based on 3D movement registration and ground reaction forces	The contribution of the counter-rotation mechanism (change in angular momentum (in kg.m2/s2)) to centre of mass acceleration in the sagittal and frontal plane will be calculated based on total body kinematics (SIMI motion - 3D movement registration) and kinetics (AMTI force plate) (calculations based on; van Dieen JH, van Leeuwen M, Faber GS. Learning to balance on one leg: motor strategy and sensory weighting. J Neurophysiol. 2015;114(5):2967-82.))	day 1