Childhood Burkitt Lymphoma Clinical Trial
Official title:
Observational - Candidate Gene Variants and Childhood/Adolescent Non-Hodgkin Lymphoma: A Preliminary Investigation
This research studies genes associated with non-Hodgkin lymphoma in young patients. Studying samples of blood and tissue from patients with cancer in the laboratory may help doctors learn more about changes that occur in DNA and identify biomarkers related to cancer
OBJECTIVES:
I. To conduct a preliminary investigation of the effects of loci strongly and consistently
associated in prior genome-wide association studies (GWAS) and validation studies of
childhood/adolescent acute lymphoblastic leukemia (ALL), adult non-Hodgkin lymphoma (NHL),
autoimmune diseases, and atopic diseases on the risk of NHL (lymphoblastic and Burkitt
lymphomas) in children and adolescents.
OUTLINE:
DNA samples are analyzed by single nucleotide polymorphism and genotyped by fluorogenic
polymerase chain reaction (PCR)-based allelic discrimination (Taqman) assays using the ABI
Prism 7900HT reverse transcriptase (RT)-PCR system.
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Observational Model: Case Control, Time Perspective: Retrospective
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