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Prediction of Delayed Toxic Cardiomyopathy in Children — SpeckleAnthra2  

Childhood Cancer Clinical Trial

Official title:
Longitudinal Analysis of Myocardial Function by Speckle Tracking Echocardiography and Prediction of Delayed Toxic Cardiomyopathy Associated With Anthracycline Therapy in Children

Clinical Trial Summary

Longitudinal analysis of myocardial function using "Speckle Tracking Echocardiography" STE analysis and prediction of delayed toxic induced cardiomyopathy in young patients who received anthracycline therapy in childhood.

Clinical Trial Description

Anthracycline therapy may have short-, medium- or long-term cardiac toxicity that impacts patient's life. The main recognized risk factors for delayed cardiotoxicity are cumulative anthracycline dose, female gender, association with mediastinal radiotherapy and young age at administration. Prediction of delayed cardiotoxicity in children population is still challenging. The "Speckle Tracking Echocardiography" (STE) method, an innovative echocardiographic technique, analyses the myocardial displacement of natural acoustic markers via a software. The objective of the study is to analyze, in young patients who received anthracycline therapy in childhood, 5-years after their inclusion in the "Speckle Anthra" study and first STE results, the evolution of myocardial function using STE method. ;

Study Design

Related Conditions & MeSH terms

Clinical Trial Details
NCT number NCT05781672
Study type Interventional
Source University Hospital, Montpellier
Contact VINCENTI Marie, PH
Phone 04 67 33 66 39
Email m-vincenti@chu-montpellier.fr
Status Recruiting
Phase N/A
Start date March 16, 2023
Completion date September 30, 2025
View Details
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