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Approaches to Identify Early Biomarkers and Pathogenesis of Anthracycline Cardiotoxicity

Childhood Cancer Clinical Trial

Official title:
Integrated Basis and Translational Approaches to Identify Early Biomarkers and Pathogenesis of Anthracycline Cardiotoxicity

Clinical Trial Summary

Early microRNAs (miRs) and Cardiac Magnetic Resonance (CMR)-derived strain analysis and detection of genes contributing to Anthracycline-Induced Cardiotoxicity (AIC) sensitivity and resistance will identify pediatric cancer patients most and least likely to develop AIC.

Clinical Trial Description

Plan is to enroll 110 children and adults (≥9 years old) newly diagnosed at CCMC and Nationwide Children's Hospital (55 per institution) who will receive anthracyclines as part of their chemotherapy regimen. The duration of study participation will be approximately a year. Patients will have a total of four study visits: Baseline 1 week after patient's anthracycline cumulative dose hits between 60 and 100 mg/m2 After the patient has completed maximal therapy One year after completion of anthracycline treatments Study tasks for all four visits will be: Collection of clinical data Blood draw for micro RNA and Biomarkers Cardiac MRI Echocardiogram One time blood draw for genetics ;

Study Design

Related Conditions & MeSH terms

Clinical Trial Details
NCT number NCT04036045
Study type Observational
Source Connecticut Children's Medical Center
Contact Olga Salazar, MD
Phone 860-545-9400
Email Otoro@connecticutchildrens.org
Status Not yet recruiting
Phase
Start date January 2025
Completion date August 2030
View Details
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