Child Clinical Trial
Official title:
Clinical Study on the Effects of Propofol for Treatment on Emergence Agitation After Sevoflurane Anesthesia in Pediatric Strabismus Surgery
This study aimed to verify the effects of propofol for treatment on emergence agitation (EA) after sevoflurane anesthesia in pediatric strabismus surgery.
Sevoflurane with rapid anesthetic induction and emergence, hemodynamic stability, and
nonirritating airway properties, has acquired widespread acceptance in children. However,
sevoflurane has been reported to be associated with emergence agitation in children, with a
reported incidence of up to 80%. In severe case, it cause injury to the child or to the
surgical site and lead to the accidental removal of surgical dressings and intravenous
catheters. In case of intense agitation with high risk of self-injury, pharmacologic
intervention seems reasonable. Pharmacologic treatment of emergence agitation relies on the
administration of IV sedative agents (IV midazolam 0.1 mg/kg12 or propofol 0.5 or 1 mg/kg)
or opioid agents (IV fentanyl 1 or 2 mcg/kg). However, these treatments are empirical and
were extrapolated from pharmacologic preventive studies performed at the end of surgery or
from personal experience. To the investigators knowledge, there is no risk of recurrence of
EA after a first episode. Consequently, EA is not per se a factor of increased duration of
PACU (post-anaesthesia care unit ) stay, but sedative or opioid agents administered
postoperatively to alleviate it might prolong this stay.
Therefore, the investigators design a study to confirm statistically effect of propofol for
treatment on emergence agitation after sevoflurane anesthesia in pediatric strabismus
surgery through PAED scale. Furthermore duration of PACU stay is checked after propofol
administration.
;
Allocation: Randomized, Endpoint Classification: Efficacy Study, Intervention Model: Parallel Assignment, Masking: Double Blind (Caregiver, Investigator), Primary Purpose: Treatment
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