Child Clinical Trial - The Role of Brain-derived Neurotropic Factor in

Status Completed

Clinical Trial Summary

This doctoral thesis has the aim to identify the role of Brain-derived neurotropic factor in the relationship between physical fitness/activity and executive functions in typically developing children and children with Autism Spectrum Disorder, Development Coordination Disorder , Attention Hyperactive Disorder.

Clinical Trial Description

Nowadays children are getting more inactive and participate less in sports or daily physical activity. Previous studies have shown that a good physical fitness is associated with improved cognitive functions. While being physical active, physiological changes take places in the brain. Brain-derived neurotropic factor is one of the neurotropins that plays a crucial role in this process. Executive functions are cognitive processes that are responsible for organizing and controlling goal-directed actions. These functions are developing during childhood and play an important role in daily- and school functioning. This doctoral thesis has the aim to identify the role of Brain-derived neurotropic factor in the relationship between physical fitness/activity and executive functions in children. In a first trail the effect of physical fitness and physical training on executive functioning and levels of Brain-derived neurotropic factor will be studied. In a second trail the research question is expanded by investigating the same relations in children with Autism Spectrum Disorder, Development Coordination Disorder , Attention Hyperactive Disorder. Protocol trail 1: The included (typically developing) children will be randomized and stratified for level of physical fitness into 2 groups: the intervention group and the control group. The intervention group will receive physical activity training 2 times a week during 8 weeks. The control group will receive no additional training. At the beginning and the end of the training period both the intervention and control group will be tested for physical fitness and level of executive functioning. Protocol trail 2: Identical protocol to trail 1 except the participants will be children with Autism Spectrum Disorder, Development Coordination Disorder , Attention Hyperactive Disorder in stead of typically developing children. ;

Study Design

Related Conditions & MeSH terms

Clinical Trial Details

NCT number	NCT02503579
Study type	Interventional
Source	University Ghent
Contact
Status	Completed
Phase	N/A
Start date	August 2015
Completion date	February 2016

View Details

See also
Status	Clinical Trial	Phase
Recruiting	`NCT06320626` - Pharmacokinetic-guided Dosing of Emicizumab	Phase 4
Completed	`NCT04011852` - The Role of Chest Electrical Impedance Tomography in the Pediatric Ventilator Weaning
Completed	`NCT03497663` - VIA Family - Family Based Early Intervention Versus Treatment as Usual	N/A
Recruiting	`NCT05016271` - Health Benefits of Air Purifiers in Primary School Students	N/A
Completed	`NCT02551978` - Kids Obesity Prevention Program - Study (KOP)	N/A
Completed	`NCT02240368` - Performance Evaluation of the Depth of Anesthesia Monitors in Pediatric Surgery
Completed	`NCT03946137` - Chest Therapy and Postural Education in Children With Cerebral Palsy	N/A
Completed	`NCT01918020` - Impact Study of Minnesota SNAP-Ed Health and Nutrition Education Programs	N/A
Completed	`NCT01267097` - The PAC Study: Parents as Agents of Change in Pediatric Weight Management	N/A
Recruiting	`NCT04022460` - Using Personal Mobile Technology to Identify Obstructive Sleep Apnea in Children With Down Syndrome (UPLOAD)
Completed	`NCT05538039` - Reducing Anxiety of Children and Their Parents in the Pre-elective Surgery Process	N/A
Completed	`NCT03156465` - Iowa Cochlear Implant Clinical Research Center Hybrid L24 and Standard Cochlear Implants in Profoundly Deaf Infants	N/A
Not yet recruiting	`NCT05914324` - Outpatient Pediatric Pulse Oximeters in Africa	N/A
Not yet recruiting	`NCT04827108` - Psychometric Properties of the Chinese Version of PeNAT
Recruiting	`NCT04888195` - Symptom Clusters in Hong Kong Chinese Children With Blood Cancer
Not yet recruiting	`NCT04853303` - VR to Improve CINV, Sleep and Pain Among Children With Cancer in HK	N/A
Completed	`NCT05374902` - Efficacy of Animation, Buzzy, and Multiple Interventions on Pain in Children	N/A
Completed	`NCT04665453` - Dexmedetomidine and Melatonin for Sleep Induction for EEG in Children	N/A
Completed	`NCT04082247` - Healthy Children 2021 Study in Childcare Centers	N/A
Completed	`NCT02858531` - Predictive Tracking of Patient Flow in the Emergency Services During the Virus Winter Epidemics

Clinical trials are conducted in a series of steps, called phases - each phase is designed to answer a separate research question.

Phase 1: Researchers test a new drug or treatment in a small group of people for the first time to evaluate its safety, determine a safe dosage range, and identify side effects.
Phase 2: The drug or treatment is given to a larger group of people to see if it is effective and to further evaluate its safety.
Phase 3: The drug or treatment is given to large groups of people to confirm its effectiveness, monitor side effects, compare it to commonly used treatments, and collect information that will allow the drug or treatment to be used safely.
Phase 4: Studies are done after the drug or treatment has been marketed to gather information on the drug's effect in various populations and any side effects associated with long-term use.

The Role of Brain-derived Neurotropic Factor in the Relationship Between Executive Function and Physical Training

Clinical Trial Summary

Clinical Trial Description

Study Design

Related Conditions & MeSH terms