Child, Only Clinical Trial
Official title:
As Needed Versus Regular Use of Intranasal Corticosteroid in Children With Perennial Allergic Rhinitis: A Randomized Controlled Trial
Allergic rhinitis in children is common. According to the international study of asthma and allergies in childhood (ISAAC) phase III, the global prevalence of allergic rhinitis among children is increasing to 40.1% and the prevalence of allergic rhinitis in Bangkok area in 2018, among children aged 6-7 and 13-14 years was 16.32%. This disease is a global health problem affecting quality of life of patients in daily life, work, study and sleep. Intranasal corticosteroid is the most effective treatment for allergic rhinitis. From real world evidence; most of allergic rhinitis patient use the drug when symptoms worsen. In children, the use of intranasal corticosteroid may cause minor local side effects such as dryness, burning sensation or epistaxis. In some intranasal corticosteroid, long-term use may result in decreased growth compared to placebo which make parents concern. The investigators interested in studying the efficacy of intranasal corticosteroid comparing between daily use and as needed use in children with allergic rhinitis. To study the appropriate form of treatment to increase cooperation. Patient will have a better quality of life and reduce the risk of side effects from prolonged use of intranasal corticosteroid. From the literature review, it was found that most studies were conducted among adult patients with seasonal allergic rhinitis In Thailand in 2020, Thongngam et al. studied the efficacy of intranasal corticosteroid was compared between daily use and as needed use in adult patients with perennial allergic rhinitis. The results of the study concluded that the daily use group can reduced more TNSS (total nasal symptoms score) but was not statistically significant and had a greater increase in peak nasal inspiratory flow (PNIF) compared to as needed group. Interestingly, the quality of life assessment (RCQ-36 score) in both2 groups improved equally, In as needed group, the cumulative dose was 51% lower than the daily dose group. The investigators want to compare the efficacy of intranasal corticosteroid between daily versus as needed use in children with perennial allergic rhinitis which had not been studied before.
8 week Double-blinded placebo controlled randomized controlled trial to compare the efficacy between as-needed and regular use of INCS in children with perennial allergic rhinitis. ;
| Status | Clinical Trial | Phase | |
|---|---|---|---|
| Completed |
NCT06190457 -
Safety and Efficacy of Intrathecal Rituximab in 16 Children of Stage Ⅲ、ⅣNon-Hodgkin Lymphoma
|
||
| Recruiting |
NCT04691349 -
CAR-T for r/r Malignant Tumors in Children
|
Early Phase 1 | |
| Not yet recruiting |
NCT06455592 -
Effect of APA on Sleep Quality in Children With Cancer From 5 to 16 Years
|
N/A | |
| Not yet recruiting |
NCT05566951 -
Technology-Based Psychosocial Empowerment Program for Home Care of Children With Cancer and Their Parents
|
N/A | |
| Not yet recruiting |
NCT05806983 -
Evaluation of the Efficiency of the Technology-Based Psychosocial Empowerment Program Program
|
N/A | |
| Recruiting |
NCT05329467 -
Validation of Pain Assessment Scale Faces Thermometer Scale (FTS)
|
N/A | |
| Not yet recruiting |
NCT04016506 -
Epidemiology, Management and Complications Related to Pancreatic Trauma in Children
|
||
| Recruiting |
NCT05761847 -
Pediatric Medication Therapy Management Trial
|
N/A | |
| Not yet recruiting |
NCT06291012 -
Stopping Pneumonia Antibiotherapy Regimen Early
|
Phase 4 | |
| Not yet recruiting |
NCT05943587 -
The Development and Evaluation of Pain Neuroscience Education in Children
|
N/A | |
| Recruiting |
NCT05109013 -
Juvenile Essential Arterial Hypertension and Vascular Function
|
||
| Completed |
NCT04846400 -
Pilot Study of a Self-Supporting Nasopharyngeal Airway in Hypotonia
|
N/A | |
| Completed |
NCT03312881 -
Neuropathic Pain in Children: Multimodal Assessment and Diagnosis
|
||
| Completed |
NCT04040036 -
Effects of Virtual Reality on Pain, Fear and Anxiety During Blood Draw in Children Aged 5-12 Years Old
|
N/A | |
| Completed |
NCT04334733 -
The Impact of Preprocedural Animation About Echocardiography Display and Kaleidoscope Display on Anxiety in Children
|
N/A | |
| Completed |
NCT06220383 -
Evaluation of The Effect of Crowns Applied With Hall Technique on Occlusion
|
N/A | |
| Completed |
NCT03941392 -
Nutritional Study in Spanish Pediatric Population
|
||
| Completed |
NCT03244332 -
HEMOCC Study. Hemostasis in Cirrhotic Children.
|
N/A | |
| Not yet recruiting |
NCT06299267 -
The Effect of Dual Task on Manual Skill Performance in Children and Adolescents
|
N/A | |
| Active, not recruiting |
NCT04070131 -
Horse Assisted Rehabilitation Postoncologic Treatment in Children and Adolescents: Physical and Psychological Effects
|
N/A |