Child Development Clinical Trial
Official title:
Clinical and Genetic Markers of Bone Metabolism in Children Under One Year of Age in the Kazakh Population
The study of children under one year of age for molecular genetic testing-VDR (rs1544410, rs2228570), RANKL (rs9594738, rs9594759) with the study of the frequency distribution of alleles and genotypes by polymorphisms, analysis of the relationship of molecular genetic markers with indicators of bone metabolism.
Status | Recruiting |
Enrollment | 245 |
Est. completion date | March 1, 2024 |
Est. primary completion date | March 1, 2024 |
Accepts healthy volunteers | |
Gender | All |
Age group | 1 Day to 1 Year |
Eligibility | Inclusion Criteria: -Children 0 -12 months old Exclusion Criteria: - Musculoskeletal system diseases; - Severe chronic somatic diseases; - Supplementation of vitamin D in a therapeutic dose; - Lack of consent of the parents or legal representatives to participate in the study. |
Country | Name | City | State |
---|---|---|---|
Kazakhstan | Irina Kim | Aktobe |
Lead Sponsor | Collaborator |
---|---|
West Kazakhstan Medical University |
Kazakhstan,
Antonucci R, Locci C, Clemente MG, Chicconi E, Antonucci L. Vitamin D deficiency in childhood: old lessons and current challenges. J Pediatr Endocrinol Metab. 2018 Mar 28;31(3):247-260. doi: 10.1515/jpem-2017-0391. — View Citation
Bao L, Chen M, Lei Y, Zhou Z, Shen H, Le F. Association between vitamin D receptor BsmI polymorphism and bone mineral density in pediatric patients: A meta-analysis and systematic review of observational studies. Medicine (Baltimore). 2017 Apr;96(17):e671 — View Citation
Basit S. Vitamin D in health and disease: a literature review. Br J Biomed Sci. 2013;70(4):161-72. doi: 10.1080/09674845.2013.11669951. — View Citation
Bizzaro G, Antico A, Fortunato A, Bizzaro N. Vitamin D and Autoimmune Diseases: Is Vitamin D Receptor (VDR) Polymorphism the Culprit? Isr Med Assoc J. 2017 Jul;19(7):438-443. — View Citation
Type | Measure | Description | Time frame | Safety issue |
---|---|---|---|---|
Primary | Optimization of the method for diagnosing bone metabolism disorders in children under one year old in the Kazakh population | The state of bone metabolism was assessed using the quantitative content of calcium, phosphorus, vitamin D, osteocalcin, and parathyroid hormone. | 2 years |
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