Child Development Clinical Trial
Official title:
Study on the Molecular Structure and Content of Human Milk Oligosaccharides (HMOs) in Breast Milk and Its Effect on Infant Health in China
In the study, the composition and content of human milk oligosaccharides in premature delivery mothers in China will be examined to investigate the differences in oligosaccharide concentrations in preterm breast milk from different gestational weeks. This study will fill a gap in human milk research in China, provide theoretical basis for the superiority of breastfeeding, and provide more powerful nutritional support for the catch-up growth of preterm infants
Objective:
1. Analyze and compare the differences in HMOs components among mothers who give birth at
different gestational weeks;
2. Longitudinal observation of weekly changes in HMOs concentrations of premature mothers
within 1 month of delivery;
3. Validate the association between HMOs components in preterm mothers and fecal intestinal
flora in infants at 6 months of age.
Research content
1. The LC-MS method will be used to detect the content of HMOs in preterm mothers and
compared with the corresponding components in term breast milk during the postpartum
period to analyze the effects of different gestational weeks on HMOs;
2. The intestinal flora 16S rDNA high-throughput sequencing method will be used to
determine the bacterial gene profile in the fecal DNA samples of infants, and the
differences between the gestational age groups (term and preterm infants) were compared,
and the preterm infants in this group were plotted Evolution of intestinal flora within
6 months of birth;
3. Use statistical methods to verify the association between HMOs components in preterm
mothers and the establishment of intestinal flora in infants.
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