HOME Study (Health Outcomes and Measures of the Environment Study)

Child Development Clinical Trial

Official title:

Neurobehavioral Effects of Prevalent Neurotoxicants in Children: A Cohort Study of the Cincinnati Center for Children's Environmental Health

Clinical Trial Details — Status: Completed

Administrative data

• NCT number: NCT00129324
• Other study ID #: 11261-CP-001
• Secondary ID: R01ES014575P01ES
• Status: Completed
• Phase: N/A
• Start date: March 2003
• Est. completion date: August 2018

Study information

• Verified date: March 2020
• Source: National Institute of Environmental Health Sciences (NIEHS)
• Contact: n/a
• Is FDA regulated: No
• Study type: Interventional

Clinical Trial Summary

The goal of the HOME Study is to quantify the impact of low-level fetal and early childhood exposures to environmental toxicants including lead, mercury, and other metals, pesticides, polychlorinated biphenyls (PCBs), persistent organic pollutants (PBDEs/PFCs), phthalates, phenols, environmental tobacco smoke, and alcohol on child development, neurobehavior, health, and growth. The HOME Study will also evaluate meconium as a biomarker for fetal exposure and test the effectiveness of home repairs to control lead hazards and injuries in early childhood.

Description:

This study aims to examine the effects of low-level exposures to prevalent neurotoxicants on health, growth, and neurobehavior among a representative sample of children. Pregnant women were enrolled in the project around 16 weeks of gestation. In the first phase of the study, we followed children resulting from the pregnancy through the age of 36 months. The second phase extended follow-up through 72 months. Phase 3 extended follow-up to 8 years (range 7.5-10) with comprehensive neurobehavioral assessments. Phase 4 will allow follow-up at 12 years (range 11-13), and includes measures of health, growth and body composition, behavior and mental health, and neuroimaging. To address the potential adverse health risks of environmental chemicals, including persistent pollutants such as PBDEs and PFCs and other non-persistent chemicals, on fetal, infant, and child neurobehavior, the investigators are systematically examining their associations with endocrine function, cognition, learning and memory, motor skills, attention and executive function, and behavior from age 1 to 7.5-10 years. The investigators are also examining exposures at different developmental stages (in utero at 16 weeks of gestation, early childhood, school age, preadolescence) using stored biological samples and measure child neurobehavior at 1, 2, 3, 4, 5, 8, and 12 years. This longitudinal study will allow the investigators to determine the dose response, windows of susceptibility, and persistence of the association. The investigators are also examining the contribution of PBDE exposures from house dust in a subset of children who have complete sets of samples of maternal serum and child serum collected from annual visits along with extensive measures of mouthing behaviors.

Hypotheses from the four phases of the study are as follows:

1. In utero exposures measured by survey (alcohol and ETS), maternal and cord blood (lead and mercury) maternal and cord serum (ETS), and urine (pesticides) are less predictive of in utero effects of prevalent toxicants, including cognition, behavior problems, and growth compared with the same toxicants in meconium.

2. Prenatal and postnatal exposures to prevalent pesticides and ETS are associated with adverse neurobehavioral effects, and growth delay in children.

3. Higher lead exposure, measured during pregnancy and early childhood using maternal blood, cord blood, meconium and children's blood, will be associated with lower IQ scores and more behavioral problems for children with a maximal blood lead level < 5 mg/dL.

4. Children in the lead treatment arm will have: blood lead that is 2.7 mg/dL lower, higher IQ scores, greater growth velocity, and fewer behavioral problems than children in the control group.

5. Levels of lead in dust, soil and water will be significantly lower for housing units in the lead treatment arm compared with the injury control arm at 36 and 48 month home visits.

6. A multifactorial, housing intervention will reduce residential injury by 30 percent among children in the injury treatment arm compared with those in the lead treatment arm.

7. Prenatal and Postnatal exposures to PBDEs and PFCs are associated with altered thyroid hormone levels and deficits in infant and child neurobehavior

8. With increasing child age, PBDE exposure from household dust becomes a stronger predictor of child serum PBDE concentration than exposure from placenta or breast milk.

9. Developmental PBDE and PFC exposures are associated with internalizing symptoms.

10. Developmental PBDE and PFC exposures are associated with adverse changes in anatomical structure, neurochemistry, organization of white matter tracts, and connectivity of neural networks.

11. PFAS affect the gene expression and function of several biological pathways that program the fetus/infant towards a 'thrifty phenotype'. This leads to accelerated early childhood growth, increased fat mass, and features of metabolic syndrome.

Recruitment information / eligibility

• Status: Completed
• Enrollment: 468
• Est. completion date: August 2018
• Est. primary completion date: August 2018
• Accepts healthy volunteers: No
• Gender: Female
• Age group: 18 Years and older

Eligibility

Inclusion Criteria:

• Pregnancy

• Participating prenatal practice/clinic

• Participating hospital

Exclusion Criteria:

• Residence outside study area

• Plans to move outside study area within 1 year

• Home built after 1978

• Less than 18 years of age

• Beyond 19 weeks of gestation

• Diagnosis of diabetes

• Diagnosis of seizure disorder (taking anti-seizure medication)

• Diagnosis of thyroid disorder

• Diagnosis of AIDS or positive HIV test

• Diagnosis of bipolar disorder

• Diagnosis of schizophrenia

• Diagnosis of cancer resulting in radiation treatment or chemotherapy

Related Conditions & MeSH terms

• Child Development
• Environmental Exposures
• Lead and Injury Reduction

Intervention

Procedure:
• Lead Hazard Control Intervention
Prior to their child's birth, participants randomized to Lead Reduction Group received lead hazard reduction controls to reduce residential exposure to lead.
• Injury Hazard Control Intervention
Between 3 and 6 months of age, participants randomized to Injury Reduction Arm received injury hazard controls to reduce the number of residential injuries.

Locations

Country	Name	City	State
United States	Cincinnati Children's Environmental Health Center	Cincinnati	Ohio

Sponsors (1)

Lead Sponsor	Collaborator
National Institute of Environmental Health Sciences (NIEHS)

Country where clinical trial is conducted

United States, 

References & Publications (81)

Barnard H, Rao R, Xu Y, Froehlich T, Epstein J, Lanphear BP, Yolton K. Association of the Conners' Kiddie Continuous Performance Test (K-CPT) Performance and Parent-Report Measures of Behavior and Executive Functioning. J Atten Disord. 2018 Sep;22(11):105 — View Citation

Beebe DW, Rausch J, Byars KC, Lanphear B, Yolton K. Persistent snoring in preschool children: predictors and behavioral and developmental correlates. Pediatrics. 2012 Sep;130(3):382-9. doi: 10.1542/peds.2012-0045. Epub 2012 Aug 13. — View Citation

Bowers K, Khoury J, Sucharew H, Xu Y, Chen A, Lanphear B, Yolton K. Early infant attention as a predictor of social and communicative behavior in childhood. International Journal of Behavioral Development 2018:0165025418797001.

Braun JM, Bellinger DC, Hauser R, Wright RO, Chen A, Calafat AM, Yolton K, Lanphear BP. Prenatal phthalate, triclosan, and bisphenol A exposures and child visual-spatial abilities. Neurotoxicology. 2017 Jan;58:75-83. doi: 10.1016/j.neuro.2016.11.009. Epub — View Citation

Braun JM, Chen A, Romano ME, Calafat AM, Webster GM, Yolton K, Lanphear BP. Prenatal perfluoroalkyl substance exposure and child adiposity at 8 years of age: The HOME study. Obesity (Silver Spring). 2016 Jan;24(1):231-7. doi: 10.1002/oby.21258. Epub 2015 — View Citation

Braun JM, Daniels JL, Poole C, Olshan AF, Hornung R, Bernert JT, Khoury J, Needham LL, Barr DB, Lanphear BP. Prenatal environmental tobacco smoke exposure and early childhood body mass index. Paediatr Perinat Epidemiol. 2010 Nov;24(6):524-34. doi: 10.1111 — View Citation

Braun JM, Daniels JL, Poole C, Olshan AF, Hornung R, Bernert JT, Xia Y, Bearer C, Barr DB, Lanphear BP. A prospective cohort study of biomarkers of prenatal tobacco smoke exposure: the correlation between serum and meconium and their association with infa — View Citation

Braun JM, Froehlich T, Kalkbrenner A, Pfeiffer CM, Fazili Z, Yolton K, Lanphear BP. Brief report: are autistic-behaviors in children related to prenatal vitamin use and maternal whole blood folate concentrations? J Autism Dev Disord. 2014 Oct;44(10):2602- — View Citation

Braun JM, Hornung R, Chen A, Dietrich KN, Jacobs DE, Jones R, Khoury JC, Liddy-Hicks S, Morgan S, Vanderbeek SB, Xu Y, Yolton K, Lanphear BP. Effect of Residential Lead-Hazard Interventions on Childhood Blood Lead Concentrations and Neurobehavioral Outcom — View Citation

Braun JM, Kalkbrenner AE, Calafat AM, Bernert JT, Ye X, Silva MJ, Barr DB, Sathyanarayana S, Lanphear BP. Variability and predictors of urinary bisphenol A concentrations during pregnancy. Environ Health Perspect. 2011 Jan;119(1):131-7. doi: 10.1289/ehp.1 — View Citation

Braun JM, Kalkbrenner AE, Calafat AM, Yolton K, Ye X, Dietrich KN, Lanphear BP. Impact of early-life bisphenol A exposure on behavior and executive function in children. Pediatrics. 2011 Nov;128(5):873-82. doi: 10.1542/peds.2011-1335. Epub 2011 Oct 24. — View Citation

Braun JM, Kalkbrenner AE, Just AC, Yolton K, Calafat AM, Sjödin A, Hauser R, Webster GM, Chen A, Lanphear BP. Gestational exposure to endocrine-disrupting chemicals and reciprocal social, repetitive, and stereotypic behaviors in 4- and 5-year-old children — View Citation

Braun JM, Kalkwarf HJ, Papandonatos GD, Chen A, Lanphear BP. Patterns of early life body mass index and childhood overweight and obesity status at eight years of age. BMC Pediatr. 2018 May 11;18(1):161. doi: 10.1186/s12887-018-1124-9. — View Citation

Braun JM, Kalloo G, Chen A, Dietrich KN, Liddy-Hicks S, Morgan S, Xu Y, Yolton K, Lanphear BP. Cohort Profile: The Health Outcomes and Measures of the Environment (HOME) study. Int J Epidemiol. 2017 Feb 1;46(1):24. doi: 10.1093/ije/dyw006. — View Citation

Braun JM, Lanphear BP, Calafat AM, Deria S, Khoury J, Howe CJ, Venners SA. Early-life bisphenol a exposure and child body mass index: a prospective cohort study. Environ Health Perspect. 2014 Nov;122(11):1239-45. doi: 10.1289/ehp.1408258. Epub 2014 Jul 29 — View Citation

Braun JM, Yolton K, Dietrich KN, Hornung R, Ye X, Calafat AM, Lanphear BP. Prenatal bisphenol A exposure and early childhood behavior. Environ Health Perspect. 2009 Dec;117(12):1945-52. doi: 10.1289/ehp.0900979. Epub 2009 Oct 6. — View Citation

Braun JM, Yolton K, Stacy SL, Erar B, Papandonatos GD, Bellinger DC, Lanphear BP, Chen A. Prenatal environmental chemical exposures and longitudinal patterns of child neurobehavior. Neurotoxicology. 2017 Sep;62:192-199. doi: 10.1016/j.neuro.2017.07.027. E — View Citation

Buck CO, Eliot MN, Kelsey KT, Calafat AM, Chen A, Ehrlich S, Lanphear BP, Braun JM. Prenatal exposure to perfluoroalkyl substances and adipocytokines: the HOME Study. Pediatr Res. 2018 Dec;84(6):854-860. doi: 10.1038/s41390-018-0170-1. Epub 2018 Sep 13. — View Citation

Buckley JP, Engel SM, Braun JM, Whyatt RM, Daniels JL, Mendez MA, Richardson DB, Xu Y, Calafat AM, Wolff MS, Lanphear BP, Herring AH, Rundle AG. Prenatal Phthalate Exposures and Body Mass Index Among 4- to 7-Year-old Children: A Pooled Analysis. Epidemiol — View Citation

Byars KC, Yolton K, Rausch J, Lanphear B, Beebe DW. Prevalence, patterns, and persistence of sleep problems in the first 3 years of life. Pediatrics. 2012 Feb;129(2):e276-84. doi: 10.1542/peds.2011-0372. Epub 2012 Jan 4. — View Citation

Chen A, Yolton K, Rauch SA, Webster GM, Hornung R, Sjödin A, Dietrich KN, Lanphear BP. Prenatal polybrominated diphenyl ether exposures and neurodevelopment in U.S. children through 5 years of age: the HOME study. Environ Health Perspect. 2014 Aug;122(8): — View Citation

Dasu K, Nakayama SF, Yoshikane M, Mills MA, Wright JM, Ehrlich S. An ultra-sensitive method for the analysis of perfluorinated alkyl acids in drinking water using a column switching high-performance liquid chromatography tandem mass spectrometry. J Chroma — View Citation

Donauer S, Altaye M, Xu Y, Sucharew H, Succop P, Calafat AM, Khoury JC, Lanphear B, Yolton K. An Observational Study to Evaluate Associations Between Low-Level Gestational Exposure to Organophosphate Pesticides and Cognition During Early Childhood. Am J E — View Citation

Donauer S, Chen A, Xu Y, Calafat AM, Sjodin A, Yolton K. Prenatal exposure to polybrominated diphenyl ethers and polyfluoroalkyl chemicals and infant neurobehavior. J Pediatr. 2015 Mar;166(3):736-42. doi: 10.1016/j.jpeds.2014.11.021. Epub 2014 Dec 16. — View Citation

Ehrhardt J, Xu Y, Khoury J, Yolton K, Lanphear B, Phelan K. Cognitive and motor abilities of young children and risk of injuries in the home. Inj Prev. 2017 Feb;23(1):16-21. doi: 10.1136/injuryprev-2016-042031. Epub 2016 Jul 19. — View Citation

Engel SM, Bradman A, Wolff MS, Rauh VA, Harley KG, Yang JH, Hoepner LA, Barr DB, Yolton K, Vedar MG, Xu Y, Hornung RW, Wetmur JG, Chen J, Holland NT, Perera FP, Whyatt RM, Lanphear BP, Eskenazi B. Prenatal Organophosphorus Pesticide Exposure and Child Neu — View Citation

Geraghty SR, Khoury JC, Morrow AL, Lanphear BP. Reporting individual test results of environmental chemicals in breastmilk: potential for premature weaning. Breastfeed Med. 2008 Dec;3(4):207-13. doi: 10.1089/bfm.2008.0120. — View Citation

Goetz AR, Beebe DW, Peugh JL, Mara CA, Lanphear BP, Braun JM, Yolton K, Stark LJ. Longer sleep duration during infancy and toddlerhood predicts weight normalization among high birth weight infants. Sleep. 2019 Feb 1;42(2). doi: 10.1093/sleep/zsy214. — View Citation

Harley KG, Engel SM, Vedar MG, Eskenazi B, Whyatt RM, Lanphear BP, Bradman A, Rauh VA, Yolton K, Hornung RW, Wetmur JG, Chen J, Holland NT, Barr DB, Perera FP, Wolff MS. Prenatal Exposure to Organophosphorous Pesticides and Fetal Growth: Pooled Results fr — View Citation

Jackson-Browne MS, Papandonatos GD, Chen A, Calafat AM, Yolton K, Lanphear BP, Braun JM. Identifying Vulnerable Periods of Neurotoxicity to Triclosan Exposure in Children. Environ Health Perspect. 2018 May 2;126(5):057001. doi: 10.1289/EHP2777. — View Citation

Kalloo G, Calafat AM, Chen A, Yolton K, Lanphear BP, Braun JM. Early life Triclosan exposure and child adiposity at 8 Years of age: a prospective cohort study. Environ Health. 2018 Mar 5;17(1):24. doi: 10.1186/s12940-018-0366-1. — View Citation

Kalloo G, Wellenius GA, McCandless L, Calafat AM, Sjodin A, Karagas M, Chen A, Yolton K, Lanphear BP, Braun JM. Profiles and Predictors of Environmental Chemical Mixture Exposure among Pregnant Women: The Health Outcomes and Measures of the Environment St — View Citation

Kato K, Wong LY, Chen A, Dunbar C, Webster GM, Lanphear BP, Calafat AM. Changes in serum concentrations of maternal poly- and perfluoroalkyl substances over the course of pregnancy and predictors of exposure in a multiethnic cohort of Cincinnati, Ohio pre — View Citation

Kingsley SL, Eliot MN, Kelsey KT, Calafat AM, Ehrlich S, Lanphear BP, Chen A, Braun JM. Variability and predictors of serum perfluoroalkyl substance concentrations during pregnancy and early childhood. Environ Res. 2018 Aug;165:247-257. doi: 10.1016/j.env — View Citation

Lanphear BP, Hornung R, Khoury J, Yolton K, Baghurst P, Bellinger DC, Canfield RL, Dietrich KN, Bornschein R, Greene T, Rothenberg SJ, Needleman HL, Schnaas L, Wasserman G, Graziano J, Roberts R. Low-level environmental lead exposure and children's intellectual function: an international pooled analysis. Environ Health Perspect. 2005 Jul;113(7):894-9. Erratum in: Environ Health Perspect. 2019 Sep;127(9):99001. — View Citation

Li N, Arbuckle TE, Muckle G, Lanphear BP, Boivin M, Chen A, Dodds L, Fraser WD, Ouellet E, Séguin JR, Velez MP, Yolton K, Braun JM. Associations of cord blood leptin and adiponectin with children's cognitive abilities. Psychoneuroendocrinology. 2019 Jan;9 — View Citation

Li N, Yolton K, Lanphear BP, Chen A, Kalkwarf HJ, Braun JM. Impact of Early-Life Weight Status on Cognitive Abilities in Children. Obesity (Silver Spring). 2018 Jun;26(6):1088-1095. doi: 10.1002/oby.22192. — View Citation

Liang H, Vuong AM, Xie C, Webster GM, Sjödin A, Yuan W, Miao M, Braun JM, Dietrich KN, Yolton K, Lanphear BP, Chen A. Childhood polybrominated diphenyl ether (PBDE) serum concentration and reading ability at ages 5 and 8 years: The HOME Study. Environ Int — View Citation

Millenson ME, Braun JM, Calafat AM, Barr DB, Huang YT, Chen A, Lanphear BP, Yolton K. Urinary organophosphate insecticide metabolite concentrations during pregnancy and children's interpersonal, communication, repetitive, and stereotypic behaviors at 8 ye — View Citation

Patel NB, Xu Y, McCandless LC, Chen A, Yolton K, Braun J, Jones RL, Dietrich KN, Lanphear BP. Very low-level prenatal mercury exposure and behaviors in children: the HOME Study. Environ Health. 2019 Jan 9;18(1):4. doi: 10.1186/s12940-018-0443-5. — View Citation

Pell T, Eliot M, Chen A, Lanphear BP, Yolton K, Sathyanarayana S, Braun JM. Parental Concern about Environmental Chemical Exposures and Children's Urinary Concentrations of Phthalates and Phenols. J Pediatr. 2017 Jul;186:138-144.e3. doi: 10.1016/j.jpeds.2 — View Citation

Percy Z, Xu Y, Sucharew H, Khoury JC, Calafat AM, Braun JM, Lanphear BP, Chen A, Yolton K. Gestational exposure to phthalates and gender-related play behaviors in 8-year-old children: an observational study. Environ Health. 2016 Aug 16;15(1):87. doi: 10.1 — View Citation

Phelan KJ, Khoury J, Xu Y, Lanphear B. Validation of a HOME Injury Survey. Inj Prev. 2009 Oct;15(5):300-6. doi: 10.1136/ip.2008.020958. — View Citation

Phelan KJ, Khoury J, Xu Y, Liddy S, Hornung R, Lanphear BP. A randomized controlled trial of home injury hazard reduction: the HOME injury study. Arch Pediatr Adolesc Med. 2011 Apr;165(4):339-45. doi: 10.1001/archpediatrics.2011.29. — View Citation

Phelan KJ, Morrongiello BA, Khoury JC, Xu Y, Liddy S, Lanphear B. Maternal supervision of children during their first 3 years of life: the influence of maternal depression and child gender. J Pediatr Psychol. 2014 Apr;39(3):349-57. doi: 10.1093/jpepsy/jst — View Citation

Prasodjo A, Pfeiffer CM, Fazili Z, Xu Y, Liddy S, Yolton K, Savitz DA, Lanphear BP, Braun JM. Serum cotinine and whole blood folate concentrations in pregnancy. Ann Epidemiol. 2014 Jul;24(7):498-503.e1. doi: 10.1016/j.annepidem.2014.04.004. Epub 2014 Apr — View Citation

Rauch SA, Braun JM, Barr DB, Calafat AM, Khoury J, Montesano AM, Yolton K, Lanphear BP. Associations of prenatal exposure to organophosphate pesticide metabolites with gestational age and birth weight. Environ Health Perspect. 2012 Jul;120(7):1055-60. doi — View Citation

Romano ME, Eliot MN, Zoeller RT, Hoofnagle AN, Calafat AM, Karagas MR, Yolton K, Chen A, Lanphear BP, Braun JM. Maternal urinary phthalate metabolites during pregnancy and thyroid hormone concentrations in maternal and cord sera: The HOME Study. Int J Hyg — View Citation

Romano ME, Kalloo G, Etzel T, Braun JM. Re: Seasonal Variation in Exposure to Endocrine-disrupting Chemicals. Epidemiology. 2017 Sep;28(5):e42-e43. doi: 10.1097/EDE.0000000000000696. — View Citation

Romano ME, Webster GM, Vuong AM, Thomas Zoeller R, Chen A, Hoofnagle AN, Calafat AM, Karagas MR, Yolton K, Lanphear BP, Braun JM. Gestational urinary bisphenol A and maternal and newborn thyroid hormone concentrations: the HOME Study. Environ Res. 2015 Ap — View Citation

Romano ME, Xu Y, Calafat AM, Yolton K, Chen A, Webster GM, Eliot MN, Howard CR, Lanphear BP, Braun JM. Maternal serum perfluoroalkyl substances during pregnancy and duration of breastfeeding. Environ Res. 2016 Aug;149:239-246. doi: 10.1016/j.envres.2016.0 — View Citation

Rosen-Carole CB, Auinger P, Howard CR, Brownell EA, Lanphear BP. Low-Level Prenatal Toxin Exposures and Breastfeeding Duration: A Prospective Cohort Study. Matern Child Health J. 2017 Dec;21(12):2245-2255. doi: 10.1007/s10995-017-2346-4. — View Citation

Sathyanarayana S, Braun JM, Yolton K, Liddy S, Lanphear BP. Case report: high prenatal bisphenol a exposure and infant neonatal neurobehavior. Environ Health Perspect. 2011 Aug;119(8):1170-5. doi: 10.1289/ehp.1003064. Epub 2011 Apr 27. — View Citation

Sears CG, Braun JM, Ryan PH, Xu Y, Werner EF, Lanphear BP, Wellenius GA. The association of traffic-related air and noise pollution with maternal blood pressure and hypertensive disorders of pregnancy in the HOME study cohort. Environ Int. 2018 Dec;121(Pt 1):574-581. doi: 10.1016/j.envint.2018.09.049. Epub 2018 Oct 6. — View Citation

Shoaff J, Papandonatos GD, Calafat AM, Ye X, Chen A, Lanphear BP, Yolton K, Braun JM. Early-Life Phthalate Exposure and Adiposity at 8 Years of Age. Environ Health Perspect. 2017 Sep 11;125(9):097008. doi: 10.1289/EHP1022. — View Citation

Shoaff JR, Romano ME, Yolton K, Lanphear BP, Calafat AM, Braun JM. Prenatal phthalate exposure and infant size at birth and gestational duration. Environ Res. 2016 Oct;150:52-58. doi: 10.1016/j.envres.2016.05.033. Epub 2016 May 26. — View Citation

Spanier AJ, Kahn RS, Kunselman AR, Hornung R, Xu Y, Calafat AM, Lanphear BP. Prenatal exposure to bisphenol A and child wheeze from birth to 3 years of age. Environ Health Perspect. 2012 Jun;120(6):916-20. doi: 10.1289/ehp.1104175. Epub 2012 Feb 14. — View Citation

Spanier AJ, Kahn RS, Kunselman AR, Schaefer EW, Hornung R, Xu Y, Calafat AM, Lanphear BP. Bisphenol a exposure and the development of wheeze and lung function in children through age 5 years. JAMA Pediatr. 2014 Dec;168(12):1131-7. doi: 10.1001/jamapediatr — View Citation

Spanier AJ, Kahn RS, Xu Y, Hornung R, Lanphear BP. Comparison of biomarkers and parent report of tobacco exposure to predict wheeze. J Pediatr. 2011 Nov;159(5):776-82. doi: 10.1016/j.jpeds.2011.04.025. Epub 2011 Jun 8. — View Citation

Spanier AJ, Wilson S, Ho M, Hornung R, Lanphear BP. The contribution of housing renovation to children's blood lead levels: a cohort study. Environ Health. 2013 Aug 27;12:72. doi: 10.1186/1476-069X-12-72. — View Citation

Stacy SL, Eliot M, Etzel T, Papandonatos G, Calafat AM, Chen A, Hauser R, Lanphear BP, Sathyanarayana S, Ye X, Yolton K, Braun JM. Patterns, Variability, and Predictors of Urinary Triclosan Concentrations during Pregnancy and Childhood. Environ Sci Techno — View Citation

Stacy SL, Papandonatos GD, Calafat AM, Chen A, Yolton K, Lanphear BP, Braun JM. Early life bisphenol A exposure and neurobehavior at 8years of age: Identifying windows of heightened vulnerability. Environ Int. 2017 Oct;107:258-265. doi: 10.1016/j.envint.2 — View Citation

Sucharew H, Khoury JC, Xu Y, Succop P, Yolton K. NICU Network Neurobehavioral Scale profiles predict developmental outcomes in a low-risk sample. Paediatr Perinat Epidemiol. 2012 Jul;26(4):344-52. doi: 10.1111/j.1365-3016.2012.01288.x. Epub 2012 May 17. — View Citation

Vuong AM, Braun JM, Sjödin A, Webster GM, Yolton K, Lanphear BP, Chen A. Prenatal Polybrominated Diphenyl Ether Exposure and Body Mass Index in Children Up To 8 Years of Age. Environ Health Perspect. 2016 Dec;124(12):1891-1897. Epub 2016 Jun 10. — View Citation

Vuong AM, Braun JM, Webster GM, Thomas Zoeller R, Hoofnagle AN, Sjödin A, Yolton K, Lanphear BP, Chen A. Polybrominated diphenyl ether (PBDE) exposures and thyroid hormones in children at age 3 years. Environ Int. 2018 Aug;117:339-347. doi: 10.1016/j.envi — View Citation

Vuong AM, Braun JM, Yolton K, Wang Z, Xie C, Webster GM, Ye X, Calafat AM, Dietrich KN, Lanphear BP, Chen A. Prenatal and childhood exposure to perfluoroalkyl substances (PFAS) and measures of attention, impulse control, and visual spatial abilities. Envi — View Citation

Vuong AM, Braun JM, Yolton K, Xie C, Webster GM, Sjödin A, Dietrich KN, Lanphear BP, Chen A. Prenatal and postnatal polybrominated diphenyl ether exposure and visual spatial abilities in children. Environ Res. 2017 Feb;153:83-92. doi: 10.1016/j.envres.201 — View Citation

Vuong AM, Webster GM, Romano ME, Braun JM, Zoeller RT, Hoofnagle AN, Sjödin A, Yolton K, Lanphear BP, Chen A. Maternal Polybrominated Diphenyl Ether (PBDE) Exposure and Thyroid Hormones in Maternal and Cord Sera: The HOME Study, Cincinnati, USA. Environ H — View Citation

Vuong AM, Yolton K, Webster GM, Sjödin A, Calafat AM, Braun JM, Dietrich KN, Lanphear BP, Chen A. Prenatal polybrominated diphenyl ether and perfluoroalkyl substance exposures and executive function in school-age children. Environ Res. 2016 May;147:556-64 — View Citation

Vuong AM, Yolton K, Xie C, Webster GM, Sjödin A, Braun JM, Dietrich KN, Lanphear BP, Chen A. Childhood polybrominated diphenyl ether (PBDE) exposure and neurobehavior in children at 8 years. Environ Res. 2017 Oct;158:677-684. doi: 10.1016/j.envres.2017.07 — View Citation

Watkins DJ, Eliot M, Sathyanarayana S, Calafat AM, Yolton K, Lanphear BP, Braun JM. Variability and predictors of urinary concentrations of phthalate metabolites during early childhood. Environ Sci Technol. 2014;48(15):8881-90. doi: 10.1021/es501744v. Epu — View Citation

Werner EF, Braun JM, Yolton K, Khoury JC, Lanphear BP. The association between maternal urinary phthalate concentrations and blood pressure in pregnancy: The HOME Study. Environ Health. 2015 Sep 17;14:75. doi: 10.1186/s12940-015-0062-3. — View Citation

Wilson SE, Baker ER, Leonard AC, Eckman MH, Lanphear BP. Understanding preferences for disclosure of individual biomarker results among participants in a longitudinal birth cohort. J Med Ethics. 2010 Dec;36(12):736-40. doi: 10.1136/jme.2010.036517. Epub 2 — View Citation

Woods MM, Lanphear BP, Braun JM, McCandless LC. Gestational exposure to endocrine disrupting chemicals in relation to infant birth weight: a Bayesian analysis of the HOME Study. Environ Health. 2017 Oct 27;16(1):115. doi: 10.1186/s12940-017-0332-3. — View Citation

Xu Y, Khoury JC, Sucharew H, Dietrich K, Yolton K. Low-level gestational exposure to mercury and maternal fish consumption: Associations with neurobehavior in early infancy. Neurotoxicol Teratol. 2016 Mar-Apr;54:61-7. doi: 10.1016/j.ntt.2016.02.002. Epub — View Citation

Xu Y, Yolton K, Khoury J. Earliest appropriate time for administering neurobehavioral assessment in newborn infants. Pediatrics. 2011 Jan;127(1):e69-75. doi: 10.1542/peds.2010-1121. Epub 2010 Dec 20. — View Citation

Yolton K, Khoury J, Xu Y, Succop P, Lanphear B, Bernert JT, Lester B. Low-level prenatal exposure to nicotine and infant neurobehavior. Neurotoxicol Teratol. 2009 Nov-Dec;31(6):356-63. doi: 10.1016/j.ntt.2009.07.004. Epub 2009 Jul 17. — View Citation

Yolton K, Xu Y, Strauss D, Altaye M, Calafat AM, Khoury J. Prenatal exposure to bisphenol A and phthalates and infant neurobehavior. Neurotoxicol Teratol. 2011 Sep-Oct;33(5):558-66. doi: 10.1016/j.ntt.2011.08.003. Epub 2011 Aug 10. — View Citation

Yolton K, Xu Y, Sucharew H, Succop P, Altaye M, Popelar A, Montesano MA, Calafat AM, Khoury JC. Impact of low-level gestational exposure to organophosphate pesticides on neurobehavior in early infancy: a prospective study. Environ Health. 2013 Sep 13;12(1 — View Citation

Zhang H, Yolton K, Webster GM, Sjödin A, Calafat AM, Dietrich KN, Xu Y, Xie C, Braun JM, Lanphear BP, Chen A. Prenatal PBDE and PCB Exposures and Reading, Cognition, and Externalizing Behavior in Children. Environ Health Perspect. 2017 Apr;125(4):746-752. — View Citation

Zhang H, Yolton K, Webster GM, Ye X, Calafat AM, Dietrich KN, Xu Y, Xie C, Braun JM, Lanphear BP, Chen A. Prenatal and childhood perfluoroalkyl substances exposures and children's reading skills at ages 5 and 8years. Environ Int. 2018 Feb;111:224-231. doi — View Citation

* Note: There are 81 references in all — Click here to view all references

Outcome

Type	Measure	Description	Time frame	Safety issue
Primary	Lead reduction intervention, blood lead concentrations & neurobehavioral outcomes	Testing the efficacy of lead reduction controls in the homes of participants. Examining the effects of low level blood lead concentration on child development and neurobehavior. Measures of blood lead concentration were taken from mothers prenatally at approximately 16 and 26 weeks gestation, from cord blood at birth, and annually from participating children from 1 - 10 years of age.	16wk & 26wk gestation, birth, annually at 1y-12y
Primary	Exposure to environmental chemicals and their effects on child health, neurobehavior and development	Addressing potential adverse health risks of environmental chemicals (persistent organic pollutants, metals, cotinine, pesticides, flame retardants, BPA, and phthalates) on fetal, infant, and child neurobehavior. Examining their associations with endocrine function, body composition (DXA), neuroimaging (MRI/fMRI), cognition, learning and memory, motor skills, attention and executive function, behavior, and mental health. Also examining exposures at different developmental stages and measuring child neurobehavior.	16wk & 26wk gestation, birth, 4wk postnatal, annually years 1-12.
Primary	Injury prevention measures and household injuries	Test the efficacy of injury reduction controls in the homes of study participants. Assessed homes for potential injury hazards and installed child safety equipment. Collected parent report of injury events and validated the events against injuries tracked in the Hamilton County Injury Surveillance System	Postnatally up to age 5 years

External Links

•   Related Info