Genetic Evolution of Arboviruses in New Caledonia Between 1995 & 2024 &

Status Recruiting

Clinical Trial Summary

Arboviruses, diseases transmitted to humans by the bite of an insect vector, are a major public health problem, especially in tropical and sub-tropical countries. A promising strategy aimed at blocking the circulation of arboviruses is to release Aedes aegypti mosquitoes carrying the endosymbiotic bacterium Wolbachia. In 2019, the Wolbachia strategy was implemented in Nouméa as part of the World Mosquito Program. This intervention will modify the epidemiological profile of arboviruses in New Caledonia. Epidemiological surveillance of arboviruses requires molecular characterization of the virus contained in the serum obtained from the blood collected from patients. This molecular characterization by RNA isolation techniques, RT-qPCR monitoring and sequencing allows the construction of phylogenetic trees. In the context of the implementation of the World Mosquito Program in Nouméa, the investigators plan to follow the molecular evolution of arboviruses, over the period preceding the releases of mosquitoes carrying Wolbachia (from 1995 to 2019) then over a period of 5 years. following the releases. At the same time, the virus can be isolated by cell culture techniques and in vitro infections, allowing its study in vitro in cells or in vivo in mosquitoes. This study allows us to measure the impact of the Wolbachia strategy on the evolution of the virus's ability to replicate in cells in the presence of Wolbachia and to be transmitted by the mosquito.

Clinical Trial Description

Collection of blood samples from patients with arbovirus infection This study is a non-interventional study with retrospective part. This study will improve : - the assessment of the molecular evolution of arboviruses in the period preceding the implementation of the Wolbachia strategy - the knowledge of the impact of Wolbachia on the diversity and molecular evolution of arboviruses - the understanding of arbovirus transmission and replication mechanisms in the presence of Wolbachia ;

Study Design

Related Conditions & MeSH terms

Clinical Trial Details

NCT number	NCT04615364
Study type	Observational
Source	Institut Pasteur
Contact	Myrielle Dupont-Rouzeyrol, PhD
Phone	+687 27 75 30
Email	mdupont@pasteur.nc
Status	Recruiting
Phase
Start date	July 17, 2020
Completion date	July 17, 2025

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Clinical trials are conducted in a series of steps, called phases - each phase is designed to answer a separate research question.

Phase 1: Researchers test a new drug or treatment in a small group of people for the first time to evaluate its safety, determine a safe dosage range, and identify side effects.
Phase 2: The drug or treatment is given to a larger group of people to see if it is effective and to further evaluate its safety.
Phase 3: The drug or treatment is given to large groups of people to confirm its effectiveness, monitor side effects, compare it to commonly used treatments, and collect information that will allow the drug or treatment to be used safely.
Phase 4: Studies are done after the drug or treatment has been marketed to gather information on the drug's effect in various populations and any side effects associated with long-term use.

Genetic Evolution of Arboviruses in New Caledonia Between 1995 and 2024 and Impact of Wolbachia — DENWOLUTION

Clinical Trial Summary

Clinical Trial Description

Study Design

Related Conditions & MeSH terms