Chikungunya Virus Clinical Trial
Official title:
A Phase 1, Randomized, Placebo-Controlled, Dose-Ranging Study to Evaluate the Safety and Immunogenicity of VAL-181388 in Healthy Adults in a Non Endemic Chikungunya Region
Verified date | January 2020 |
Source | ModernaTX, Inc. |
Contact | n/a |
Is FDA regulated | No |
Health authority | |
Study type | Interventional |
This clinical study will assess the safety, tolerability, and immunogenicity of VAL-181388 in healthy subjects.
Status | Completed |
Enrollment | 60 |
Est. completion date | November 1, 2019 |
Est. primary completion date | November 1, 2019 |
Accepts healthy volunteers | Accepts Healthy Volunteers |
Gender | All |
Age group | 18 Years to 49 Years |
Eligibility |
Inclusion Criteria: - 18 to 49 years of age - Body mass index between 18 and 35 kg/m2 - In good health as determined by medical history - Female subjects must be non pregnant and non lactating and meet one of the following criteria: a) post menopausal b) surgically sterile, or c) of childbearing potential and agree to use an adequate contraception method - Male subjects must use an acceptable method of birth control through 3 months after the final vaccination - Agrees to comply with the study procedures and provides written informed consent - Has access to a consistent and reliable means of telephone contact and agrees to stay in contact with the study site for the duration of the study Exclusion Criteria: - Any ongoing, symptomatic acute or chronic illness requiring medical or surgical care - Female of childbearing potential and has a positive pregnancy test at screening or on the day of vaccination - Abnormal vital signs or screening safety laboratory test results including liver enzyme tests - Administration of an investigational product within 60 days, or 5 half-lives, whichever is longer - Administration of any live attenuated vaccines within 4 weeks before enrollment or inactive vaccines within 2 weeks before enrollment, or plans to receive any vaccine during the active vaccination period - Prior administration of a vaccine for CHIKV, dengue, Yellow Fever, tick-borne encephalitis, a history of confirmed or suspected CHIKV infection, or has lived in a CHIKV-endemic area greater than 1 year or cumulative stay of greater than 30 days in 5 years - Prior administration of investigational agent using formulations similar to VAL-181388 - A history of hypersensitivity or serious reactions to previous vaccinations - Any known or suspected autoimmune disease or immunosuppressive condition, acquired or congenital, as determined by medical history and/or physical examination - A history of inflammatory arthritis - Any neurologic disorder - Prior administration of immunoglobulins and/or any blood products within the 3 months preceding the administration of the study drug or plans to receive such products at any time during the study - Any chronic administration of an immunosuppressant or other immune modifying drug - Daily or every other day administration of antipyretic or analgesic medication - Any acute illness at the time of enrollment - Any significant disorder of coagulation requiring ongoing or intermittent treatment - A history of idiopathic urticaria - A history of alcohol abuse or drug addiction - A positive test result for drugs of abuse - The subject has any abnormality or permanent body art (eg, tattoo) that, in the opinion of the investigator, would obstruct the ability to observe local reactions at the injection site - Any condition that, in the opinion of the investigator, would pose a health risk to the subject if enrolled or could interfere with evaluation of the study drug or interpretation of study results - A positive test result for hepatitis B surface antigen, hepatitis C virus antibody, or human immunodeficiency virus types 1 or 2 antibodies - A history of active cancer (malignancy) in the last 10 years - Donation of blood or blood products > 450 mL within 30 days of dosing - Is an employee or first degree relative of the Sponsor, CRO, or study site personnel |
Country | Name | City | State |
---|---|---|---|
United States | Optimal Research | Rockville | Maryland |
Lead Sponsor | Collaborator |
---|---|
ModernaTX, Inc. | Defense Advanced Research Projects Agency |
United States,
Type | Measure | Description | Time frame | Safety issue |
---|---|---|---|---|
Primary | Types of adverse events (AEs), serious adverse events (SAEs), adverse events of special interest (AESI) and laboratory abnormalities | Through 13 months of study participation | ||
Primary | Frequency of adverse events (AEs), serious adverse events (SAEs), adverse events of special interest (AESI) and laboratory abnormalities | Through 13 months of study participation | ||
Primary | Severity of adverse events (AEs), serious adverse events (SAEs), adverse events of special interest (AESI) and laboratory abnormalities | Through 13 months of study participation | ||
Secondary | Frequency of seroconversion to CHIKV measured by neutralization assay in comparison with baseline | Through 13 months of study participation |
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