Clinical Trials Logo
  1. Home
  2. Chest Wall Disorder
  3. NCT00901485

Autotitrating Versus Standard Non-invasive Ventilation (NIV) in Newly Diagnosed Patients

Neuromuscular Disease Clinical Trial

Official title:
Autotitrating Non-invasive Ventilation (NIV) Versus Standard NIV; a Randomised Crossover Trial in Patients With Newly Diagnosed Hypoventilation

Clinical Trial Summary

The aim of the study is to compare the efficacy and tolerance of autotitrating non-invasive ventilation (NIV) versus standard NIV in patients with newly diagnosed nocturnal hypoventilation who have never experienced nocturnal, home NIV.

Clinical Trial Description

The aim of the study is to compare the effect of two types of noninvasive ventilator (a small machine that assists breathing) in patients newly diagnosed with nocturnal hypoventilation who are inexperienced in the use of noninvasive ventilation (NIV). NIV is standard therapy for patients with nocturnal hypoventilation. The most common type of NIV is bilevel pressure support which assists patient breathing by delivering different levels of air pressure during inspiration and expiration via a mask covering the nose or nose and mouth. Standard bilevel NIV (VPAP™) has been further developed to create a new automatically adjusting NIV (AutoVPAP™). Automatically adjusting NIV varies the inspiratory air pressure according to the airflow rates generated by the patient. This may improve patient comfort, hours of NIV use and recovery time. Patients over the age of 18 referred to, or under follow up at, the Royal Brompton Hospital who require domiciliary NIV but are inexperienced with use of NIV will be considered for entry into this randomised crossover study. If eligible for inclusion and willing to take part patients will be setup on automatically adjusting NIV or standard NIV, assigned in random order. At the end of one month the patient will be swapped to the alternative NIV for a further one month of domiciliary NIV treatment. At the end of each one month treatment period the patient will undergo overnight polysomnography, transcutaneous CO2 monitoring and 24 hour Holter monitoring. ;

Study Design

Related Conditions & MeSH terms

Clinical Trial Details
NCT number NCT00901485
Study type Interventional
Source ResMed
Contact
Status Completed
Phase N/A
Start date April 2009
Completion date March 2011
View Details
See also
  Status Clinical Trial Phase
Completed NCT02847299 - Comparison of a Hyperinflation Mode and Air Stacking on Neuromuscular Patients Under Volumetric Ventilation N/A
Completed NCT02551406 - Prognostic Value of Residual Hypoventilation in Mechanically Ventilated Neuromuscular Patients N/A
Completed NCT00860951 - P300 Brain Computer Interface Keyboard to Operate Assistive Technology Phase 1/Phase 2
Recruiting NCT02288299 - Long-Term Effect of LIAM on Respiratory Performance in NIV Patients Suffering From Neuromuscular Disease N/A
Completed NCT02284022 - Clinical Validation Protocol for BCI for the Communication of Patients Suffering From Neuromuscular Disorders. N/A
Completed NCT00001201 - Evaluation of Neuromuscular Disease N/A
Completed NCT00252252 - AutoVPAP Versus VPAP; Assessment of Sleep and Ventilation Phase 1
Completed NCT02153970 - Calibration and Validation of the PROMIS and Neuro-QOL Questionnaires in Cerebral Palsy and Congenital Muscular Dystrophy
Terminated NCT02317042 - Juno Perth Clinical Trial N/A
Terminated NCT02022072 - Evaluation of Vital Capacity Phase 2
Recruiting NCT04417023 - B3 for NMD: Bench to Bedside and Back
Recruiting NCT02532244 - Genetics of Pediatric-Onset Motor Neuron and Neuromuscular Diseases
Completed NCT01621984 - Therapeutic Riding and Neuromuscular Disease Phase 1
Recruiting NCT01900132 - Electrical Impedance Myography: Natural History Studies inNeuromuscular Disorders and Healthy Volunteers N/A
Completed NCT00017745 - Phenotype/Genotype Correlations in Neuromuscular Disorders N/A
Recruiting NCT01560741 - Telemedicine and Ventilator Titration in Chronic Respiratory Patients Initiating Non-invasive Ventilation Phase 1
Completed NCT01644162 - Ventilator Monitoring in Early Exacerbation Detection N/A
Completed NCT00695591 - Home Sleep Testing in Neuromuscular Disease Patients N/A
Completed NCT01611597 - Continuous Measurement of the Activity for Clinical Evaluation at Home, for Non-ambulant Neuromuscular Patients N/A
Completed NCT01518439 - Instrumental and Manual Increase of Couch in Neuromuscular Patients N/A