Non-invasive Left Ventricle Contractility dp/dt as Prognostic Marker in Chest Unit Patients

Chest Pain Clinical Trial

— dp/dt  

Official title:

Non Invasive Left Ventricle Contractility dp/dt Could be Used as a Prognostic Marker in Patients Admitted to the Emergency Department for Chest Pain

Clinical Trial Details — Status: Recruiting

Administrative data

• NCT number: NCT05416112
• Other study ID #: dp/dt
• Status: Recruiting
• Start date: June 1, 2022
• Est. completion date: September 30, 2023

Study information

• Verified date: May 2023
• Source: University of Monastir
• Contact: Nouira Semir, professor
• Phone: 73106046
• Email: semir.nouira[@]rns.tn
• Is FDA regulated: No
• Study type: Observational [Patient Registry]

Clinical Trial Summary

Ischemic heart disease is a major public health problem with high mortality rate despite the progress in management and the resources mobilized. The idea is that myocardial ischemia is generally associated with left ventricular dysfunction and, consequently, a possible alteration of the dp/dt index. As dp/dt could be assessed non-invasively by plethysmographic method, it is interesting to investigate its prognostic performance in patients with indifferentiate chest pain.

Description:

Ischemic heart disease remains a major public health problem. Despite all the advances in the prognostic approach to ischemic heart disease, the risk of occurrence of major cardiovascular events is not negligible. Several scores have been proposed for chest pain stratification risk, the most widely used are the TIMI and the GRACE scores. The dP/dt max is therefore an excellent index of contractility, corresponding to the maximum level of tension developed by an isolated cardiac muscle during the isovolumic contraction phase. the investigator theorized that a less value of dp/dt would be associated with more major cardiovascular events (MACE), because ischemia reduces myocardial contractility. The current study describes non-invasive plethysmographic dp/dt changes, which could be used as a prognostic marker in patients presenting at the emergency department with acute chest pain.

Recruitment information / eligibility

• Status: Recruiting
• Enrollment: 500
• Est. completion date: September 30, 2023
• Est. primary completion date: May 31, 2023
• Accepts healthy volunteers: No
• Gender: All
• Age group: 18 Years and older

Eligibility

Inclusion criteria:

• age over 18 years old,
• acute chest pain

Exclusion criteria:

• traumatic chest pain,
• hemodynamic instability;
• arrhythmias;
• holders of a pacemaker;
• STEMI

Related Conditions & MeSH terms

• Chest Pain

Locations

Country	Name	City	State
Tunisia	Emergency Departement	Monastir

Sponsors (1)

Lead Sponsor	Collaborator
University of Monastir

Country where clinical trial is conducted

Tunisia, 

Outcome

Type	Measure	Description	Time frame	Safety issue
Primary	MACE	the occurrence of a major cardiovascular event (MACE)	one month
Primary	MACE	: the occurrence of a major cardiovascular event (MACE)	SIX MONTHS