Clinical Trials Logo

Clinical Trial Summary

Ventricular tachycardia is one of the commonest cause of sudden death in chronic chagas disease. As most ventricular tachycardias originate from scar in patients with heart disease, catheter ablation is an important step in patient treatment. Identification of fibrosis prior to ablation of sustained ventricular tachycardia (SVT) might reduce the time of anesthesia, procedure time, radiation exposure and possibly the risk of complications. Knowledge of arrhythmia circuit within scar allows planning strategies for each procedure. Condreanu et al. stablished that voltages inferior to 6.52 mV (unipolar) and 1.54mV (bipolar) are useful tools in detecting scar during electroanatomic mapping. Accuracy, however when compared to magnetic resonance imaging is limited due to difficulties in maintaining good contact between ablation catheter and ventricular wall. Contact force catheters might help increase accuracy of voltage mapping because they allow detection of poor contact areas. Although the threshold for identification of scar in ischemic and non ischemic patients during electroanatomical mapping is already known, this parameters still lacking for chronic chagasic individuals. A marked qualitative histological difference between these fibrous scars supports the hypothesis that voltage scar in chagasics might be different. Catheter ablation contact with endo and epicardial surface is an important issue when ablating arrhythmias. Conventional catheter ablation is not equipped with sensors capable of detecting degree of contact with the target. To our knowledge, the literature lacks information in regard to late lesions produced by a known contact force pressure "in vivo". The pattern of electrical activation in these patients and their relationship with local coronary veins for resynchronization likely to approach through the coronary sinus can be useful in defining chagasic that can benefit from resynchronization.

1. Compare endocardial and epicardial impedance and voltage using CARTO 3 with fibrosis on 3T MRI

2. Correlate areas of late activation within scar during activating mapping in sinus rhythm with different signal intensity in 3T MRI

3. Evaluate the influence of contact pressure during application of radiofrequency in making fibrosis analyzed 30 days after the procedure using a 3T MRI.

4. Assess the site of latest left ventricular activation in sinus rhythm and correlate with the coronary veins location


Clinical Trial Description

n/a


Study Design

Observational Model: Cohort, Time Perspective: Prospective


Related Conditions & MeSH terms


NCT number NCT01847378
Study type Observational
Source Federal University of São Paulo
Contact Lucas H Oliveira, MD
Phone +55(11)99750937
Email lucas.hollanda@unifesp.br
Status Recruiting
Phase N/A
Start date June 2013
Completion date August 2015

See also
  Status Clinical Trial Phase
Completed NCT04153006 - Comparison of Fingerstick Versus Venous Sample for Troponin I.
Recruiting NCT03664973 - Serratus Plane Block for Rib Fractures N/A
Completed NCT02905383 - The Effect of Exercise on Physical Function and Health in Older People After Discharge From Hospital N/A
Not yet recruiting NCT05649891 - Checklists Resuscitation Emergency Department N/A
Withdrawn NCT03906812 - A Randomized Trial of Telemetry Compared With Unmonitored Floor Admissions in ED Patients With Low-Risk Chest Pain N/A
Active, not recruiting NCT02892903 - In the Management of Coronary Artery Disease, Does Routine Pressure Wire Assessment at the Time of Coronary Angiography Affect Management Strategy, Hospital Costs and Outcomes? N/A
Completed NCT02538861 - Acute Chest Pain Imaging in the ED With the Combine CCTA and CT Perfusion
Completed NCT02538770 - Rapid Viral Diagnostics in Adults to Reduce Antimicrobial Consumption and Duration of Hospitalization N/A
Completed NCT01931852 - Cardiac Magnetic Resonance Imaging Strategy for the Management of Patients With Acute Chest Pain and Detectable to Elevated Troponin N/A
Completed NCT02440893 - Understanding the Effect of Metformin on Corus CAD (or ASGES)
Completed NCT01665521 - Efficacy Evaluation of the HEART Pathway in Emergency Department Patients With Acute Chest Pain N/A
Recruiting NCT01542086 - Comparison of the Cost-Effectiveness of Coronary CT Angiography Versus Myocardial SPECT in Patients With Intermediate Risk of Coronary Heart Disease N/A
Completed NCT01604655 - ProspEctive First Evaluation in Chest Pain Trial N/A
Terminated NCT01836211 - High-Sensitivity Troponin T and Coronary Computed Tomography Angiography for Rapid Diagnosis of Emergency Chest Pain N/A
Completed NCT01486030 - Effect of Exercise Stress Testing on Peripheral Gene Expression Using Corus CAD (or ASGES) Diagnostic Test
Completed NCT01163019 - 2D Strain Echocardiography for Diagnosing Chest Pain in the Emergency Room N/A
Completed NCT00709670 - ComParative Diagnostic Study Between Multislice Computed Tomography (MSCT) and Stress Echography in Coronarin Patients. N/A
Completed NCT00536224 - Chest Pain Observation Unit Risk Reduction Trial N/A
Terminated NCT00221182 - Stem Cell Study for Patients With Heart Disease Phase 1/Phase 2
Completed NCT00075088 - Tele-Electrocardiography in Emergency Cardiac Care Phase 3