WISE ARIC: Retinal Photography in Women With Chest Pain

Status Completed

Clinical Trial Summary

The purposes of this study are: - To correlate the severity of retinal arteriolar narrowing and other microvascular changes, as determined from retinal photographs and video imaging, to measures of coronary microvascular function in women evaluated for chest pain. - To evaluate measures of vascular compliance with applanation tonometry and photoplethysmography using a nasal alar probe.

Clinical Trial Description

Women who meet study eligibility criteria and provide written informed consent will have a baseline physical exam, including measurements of heart rate, blood pressure, weight. Medical history will be updated, specifically cardiovascular events (hospitalizations, procedures) since last contact and current medications. Patients will be scheduled for retinal photography. Those who are currently being screened and qualify for EWISE or other ancillary studies will have retinal photography scheduled as close to the index CFR as possible and prior to receiving randomized therapy. The retinal photography will follow a standardized written protocol. For the second protocol, 100 patients will be scheduled for an appointment in the Eye clinic where they will meet the Women's Ischemic Syndrome Evaluation (WISE)/Atherosclerosis Risk in Communities (ARIC) staff and complete the baseline information and have a brief physical examination. They will then have provocative testing completed with retinal imaging. ;

Study Design

Related Conditions & MeSH terms

Chest Pain

Clinical Trial Details

NCT number	NCT00187954
Study type	Observational
Source	University of Florida
Contact
Status	Completed
Phase
Start date	June 2003
Completion date	September 2014

View Details

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