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Clinical Trial Summary

This is a single-center, retrospective clinical study to evaluate the efficacy and safety of tislelizumab combined with first-line chemotherapy in the treatment of HER2-negative advanced gastric cancer.


Clinical Trial Description

This study aims to include 60 HER-2 negative advanced gastric cancer patients who received first-line treatment with tislelizumab combined with chemotherapy in our hospital from November 1, 2020 to November 1, 2021. Clinicopathological data, blood tests and imaging data of the patients were collected. The primary endpoints evaluated were PFS and OS, and the secondary endpoints were ORR and safety. At the same time, ctDNA and peripheral cytokine status of patients as well as second-generation sequencing of tumor tissues at baseline were collected for the exploration of therapeutic efficacy related biomarkers. ;


Study Design


Related Conditions & MeSH terms


NCT number NCT06034964
Study type Observational
Source Cancer Institute and Hospital, Chinese Academy of Medical Sciences
Contact
Status Active, not recruiting
Phase
Start date November 1, 2020
Completion date November 1, 2025

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