Auricular Acupressure : Improves Oxaliplatin-induced Peripheral Neuropathy

Status Recruiting

Clinical Trial Summary

Oxaliplatin-induced peripheral neuropathy (OIPN) is a common adverse effect that becomes worse as the drug dose accumulation impacts cancer patients' daily activities and quality of life.The result of this study will determine the immediate effects of the 8-week auricular acupuncture intervention on alleviating the participants' OIPN symptoms and enhancing their quality of life. This study will continue to evaluate the carry-over effects of auricular acupuncture after the chemotherapy course ends.

Clinical Trial Description

Objectives: Oxaliplatin-induced peripheral neuropathy (OIPN) is a common adverse effect that becomes worse as the drug dose accumulation impacts cancer patients' daily activities and quality of life. This study aims to evaluate the immediate and carry-over effects of auricular acupressure on OIPN symptoms and quality of life for colorectal cancer patients. Methods : This randomized trial will recruit 76 participants with colorectal cancer and OIPN from the oncology outpatient department in Taiwan. The control group will receive usual care, whereas the experimental group will receive usual care in addition to auricular acupressure for 8 weeks. Outcomes will be assessed by using the chemotherapy-induced peripheral neuropathy assessment tool, neuropathic pain symptom inventory, pain visual analogue scale, and the European Organization for research and treatment of cancer-quality of life questionnaire-core 30. These assessment tools are used before the intervention, biweekly during the intervention, 2 weeks after the intervention, and one month after the end of the chemotherapy course. Hypothesis: Ultimately, the result of this study will determine the immediate effects of the 8-week auricular acupuncture intervention on alleviating the participants' OIPN symptoms and enhancing their quality of life. This study will continue to evaluate the carry-over effects of auricular acupuncture after the chemotherapy course ends. ;

Study Design

Related Conditions & MeSH terms

Chemotherapy
Oxaliplatin-induced Peripheral Neuropathy
Peripheral Nervous System Diseases

Clinical Trial Details

NCT number	NCT04751513
Study type	Interventional
Source	Chang Gung Memorial Hospital
Contact	TSUI-JU CHANG
Phone	+886935308271
Email	ninachang1203@gmail.com
Status	Recruiting
Phase	N/A
Start date	August 21, 2020
Completion date	August 20, 2021

View Details

See also
Status	Clinical Trial	Phase
Completed	`NCT03652727` - FX vs. ECG Guidance for PICC Insertion	N/A
Not yet recruiting	`NCT05856656` - Music Therapy as a Tool for Anxiety Reduction in Localized Breast Cancer	N/A
Active, not recruiting	`NCT02959541` - PK/PD Investigation of Calciumfolinat in Blood, Tumor and Adjacent Mucosa in Patient With Colon Cancer	N/A
Completed	`NCT00757094` - Safety and Feasibility of Fasting While Receiving Chemotherapy	N/A
Recruiting	`NCT00797238` - DNA Repair Genes and Outcomes in Patients With Stage III NSCLC	N/A
Not yet recruiting	`NCT05927857` - Ramucirumab (Cyramza), Nal-IRI (ONIVYDE) and Trifluridine/Tipiracil (Lonsurf) in Second Line Metastatic Gastric Cancer .	Phase 1/Phase 2
Recruiting	`NCT04453826` - Concurrent and Adjuvant PD1 Treatment Combined With Chemo-radiotherapy for High-risk Nasopharyngeal Carcinoma	Phase 3
Completed	`NCT04466332` - Comparison of Two ECG Guided PICC Insertion Techniques	N/A
Not yet recruiting	`NCT04055038` - Efficacy of Platinum-based Chemotherapy in Platinum-resistant Ovarian Cancer) (EPITOC)	Phase 2/Phase 3
Recruiting	`NCT03701607` - Effect of Chemotherapy on PD-L1 in NSCLC
Recruiting	`NCT04024241` - Medium Dose of Cytarabine and Mitoxantrone
Recruiting	`NCT06208436` - The Survival Outcome of Adjuvant Chemotherapy for Stage I Pancreatic Cancer
Recruiting	`NCT05306301` - Ponatinib Plus Chemotherapy in Acute Lymphoblastic Leukemia Patients	Phase 2
Active, not recruiting	`NCT02304640` - Prevalence, Severity and Determinants of Cancer-related Fatigue (CRF) in Asian Breast Cancer Patients
Completed	`NCT02298972` - Symptom Support During Chemotherapy: A Mixed Method Study in Adult Patients With Cancer	N/A
Terminated	`NCT01249001` - Relative Bioavailability of an Extemporaneous Oral Suspension of Aprepitant in Adolescents	Phase 2
Recruiting	`NCT03089892` - A Perspective Study of Cancer-related Fatigue in Gynecologic Cancer Patients Under Chemotherapy	N/A
Recruiting	`NCT05125055` - Neoadjuvant Anti-PD-1 and TP Versus TPF on Pathological Response in OSCC	Phase 2/Phase 3
Recruiting	`NCT04472403` - Platinum Plus Low-dose Long-term Continuous Intravenous Infused 5-Fluorouracil in Metastatic Nasopharyngeal Carcinoma
Terminated	`NCT02982694` - Study With Atezolizumab Plus Bevacizumab in Patients With Chemotherapy Resistant, MSI-like, Colorectal Cancer	Phase 2

Clinical trials are conducted in a series of steps, called phases - each phase is designed to answer a separate research question.

Phase 1: Researchers test a new drug or treatment in a small group of people for the first time to evaluate its safety, determine a safe dosage range, and identify side effects.
Phase 2: The drug or treatment is given to a larger group of people to see if it is effective and to further evaluate its safety.
Phase 3: The drug or treatment is given to large groups of people to confirm its effectiveness, monitor side effects, compare it to commonly used treatments, and collect information that will allow the drug or treatment to be used safely.
Phase 4: Studies are done after the drug or treatment has been marketed to gather information on the drug's effect in various populations and any side effects associated with long-term use.