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Clinical Trial Details — Status: Completed

Administrative data

NCT number NCT03207906
Other study ID # 2017-VBP-926
Secondary ID
Status Completed
Phase Phase 2
First received
Last updated
Start date October 24, 2017
Est. completion date September 18, 2018

Study information

Verified date January 2019
Source Veloce BioPharma LLC
Contact n/a
Is FDA regulated No
Health authority
Study type Interventional

Clinical Trial Summary

Paronychia is inflammation of the skin surrounding the nail that leads to secondary infection. Iatrogenic paronychia has been clearly associated with cancer chemotherapies. This phase-2 trial is a dose finding study and will evaluate topical VBP-926 solution against a vehicle control.


Recruitment information / eligibility

Status Completed
Enrollment 102
Est. completion date September 18, 2018
Est. primary completion date July 17, 2018
Accepts healthy volunteers No
Gender All
Age group 18 Years and older
Eligibility Inclusion Criteria:

- Males or females aged 18 years or older

- Acute paronychia developing during the course of their monotherapy or combination chemotherapy

- Involvement of at least one nail with a Paronychia Severity Grading score of 1 or higher

- Eastern Cooperative Oncology Group score = 2

- Life expectancy of at least 12 months as per the investigator's judgment

- Willing to provide written informed consent

- Individuals who are willing to not start any new products OTC or prescription treatments for Paronychia and discontinue any treatment the investigator feels may interfere with the evaluation of the test products

- Individuals who are already on antibiotics as prescribed by oncologist for any condition except paronychia

- Individuals who are willing to avoid using cosmetic products, creams, salves, or ointments to the treatment area(s)

Exclusion Criteria:

- Mentally incompetent or unable or not willing to give written informed consent or meet study requirements

- Without a history of a cancer diagnosis

- Without history of cancer diagnosis using chemotherapy

- Patients with paronychia requiring surgical intervention at baseline

- Patients who are already on prescribed treatment for paronychia who are not willing to discontinue this treatment and only use study drug (no washout period required)

- Neutropenia (absolute neutrophil count < 1500 cells/µL)

- Patient Human Immunodeficiency Virus (HIV) infection

- Patients with any medical condition, including alcohol or drug abuse or mental incapacity / hypersensitive to the study drug, which in judgment of the investigator will interfere with the patient's participation in the study or evaluation of study results

- Have any medical condition that, in the opinion of the investigator, may interfere with the study results or place the subject at undue risk

Study Design


Related Conditions & MeSH terms


Intervention

Drug:
VBP-926
Topical VBP-926 solution

Locations

Country Name City State
United States Montefiore Einstein Center for Cancer Care Bronx New York
United States Bryn Mawr Skin & Cancer Institute Bryn Mawr Pennsylvania
United States Oncology Specialists of Charlotte Charlotte North Carolina
United States Northwestern University Department of Dermatology Chicago Illinois
United States Ohio State University Columbus Ohio
United States Compassionate Cancer Care Fountain Valley California
United States Memorial Sloan Kettering Cancer Center New York New York
United States Washington University Saint Louis Missouri

Sponsors (1)

Lead Sponsor Collaborator
Veloce BioPharma LLC

Country where clinical trial is conducted

United States, 

Outcome

Type Measure Description Time frame Safety issue
Primary Downgrading of the 6-point Paronychia Severity Grading scale (adapted from CTCAE v4.0) in adult cancer patients with chemotherapy-associated paronychia Treatment responses will be assessed by clinical grading utilizing a morphologic 6-point Paronychia Severity Grading scale (adapted from CTCAE v4.0) and will be assessed from baseline to 8 weeks for each affected nail. 8 weeks