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Clinical Trial Details — Status: Recruiting

Administrative data

NCT number NCT06435767
Other study ID # CICAMS
Secondary ID
Status Recruiting
Phase
First received
Last updated
Start date January 1, 2024
Est. completion date January 1, 2026

Study information

Verified date May 2024
Source Cancer Institute and Hospital, Chinese Academy of Medical Sciences
Contact n/a
Is FDA regulated No
Health authority
Study type Observational

Clinical Trial Summary

Ampullary cancer, a rare malignancy, lacks standardized guidelines for effective multimodal treatment following curative resection. The opinions on whether postoperative chemotherapy can improve the long-term survival of ampullary adenocarcinoma (AA) are discordant. This aspect remains poorly studied, with comparably scant research conducted on it. log odds of positive lymph nodes (LODDS), a quantitative variable, can continuously and accurately reflect the burden of nodal involvement, which suggested a potential ability to identify AA patients benefiting from postoperative adjuvant chemotherapy (ACT). Therefore, Mainly focused issues of ACT addressed in the study are as follows: 1) the role of ACT in improving long-term survival for patients with AA after curative resection. 2) the role of LODDS in identifying postoperative AA patients benefiting from ACT. 3) compared with T and N classifications reported previously, the advantage of LODDS in identifying ACT-benefited patients. In this cohort study, a large scale of sample size was conducted by drawing on the collective experience of the National Cancer Center of China. The patients treated with radiotherapy were excluded to concentrate on the effect of ACT.


Recruitment information / eligibility

Status Recruiting
Enrollment 300
Est. completion date January 1, 2026
Est. primary completion date January 1, 2026
Accepts healthy volunteers
Gender All
Age group 18 Years to 85 Years
Eligibility Inclusion Criteria: Pathologically confirmed AA patients without distant metastasis treated with curative-intent resection Exclusion Criteria: patients who received neoadjuvant therapy or radiotherapy, as well as those with missing clinical pathological or follow-up information

Study Design


Intervention

Drug:
Adjuvant chemotherapy
In the Cancer Hospital, postoperative chemotherapy regimens and doses were planned by oncologists, with adjustments made based on drug toxicities or tumor responses.

Locations

Country Name City State
China Department of Pancreatic and Gastric Surgical Oncology, National Cancer Center/ National Clinical Research for Cancer/Cancer Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College Beijing

Sponsors (1)

Lead Sponsor Collaborator
Cancer Institute and Hospital, Chinese Academy of Medical Sciences

Country where clinical trial is conducted

China, 

Outcome

Type Measure Description Time frame Safety issue
Primary The role of adjuvant chemotherapy(ACT) The association between ACT and Overall Survival (OS) of patients 1 year
Secondary The role of adjuvant chemotherapy(ACT) The association between ACT and Cancer-specific Survival (CSS) of patients 1 year
Secondary The role of adjuvant chemotherapy(ACT) The association between ACT and Recurrence-free Survival (RFS) of patients 1 year
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