AZD6738 Plus Durvalumab in Biliary Tract Cancer

Status Recruiting

Clinical Trial Summary

This trial will enroll advanced biliary tract cancer patients who have been previously treated with immunotherapy in either the 2nd or 3rd line. Patients will be treated with AZD6738 and Durvalumab combination.

Clinical Trial Description

This is a single arm, phase II study. Advanced BTC patients who have been previously treated with immunotherapy in either the 2nd or 3rd line will be enrolled. Patients will be treated with AZD6738 and Durvalumab combination. One cycle consists of 4weeks. Response evaluation will be done every 8 weeks (every 2 cycles) of treatment 1. Tumor biopsy is mandatory: screening, after 8weeks (1st-response evaluation), at disease progression (PD) 2. blood sampling for biomarker study is mandatory: every cycles 3. To evaluate the metabolic changes by AZD6738 and Durvalumab combination : 18 F-FDG PET is mandatory : screening, after 8 weeks (1st-response evaluation) ;

Study Design

Related Conditions & MeSH terms

Clinical Trial Details

NCT number	NCT04298008
Study type	Interventional
Source	Seoul National University Hospital
Contact
Status	Recruiting
Phase	Phase 2
Start date	June 25, 2020
Completion date	December 31, 2025

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