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Nimotuzumab Concurrent With Chemoradiotherapy for Esophageal Cancer Patients

Esophageal Cancer Clinical Trial

Official title:
Nimotuzumab Concurrent With Chemoradiotherapy for Elderly or Malnourished Patients With Unresectable Esophageal Squamous Cell Carcinoma: A Phase II Study

Clinical Trial Summary

Elderly or malnourished patients diagnosed with locally advanced esophageal squamous cell carcinoma (ESCC) had poor prognosis. Radiotherpy was an important and effective treatment in treating ESCC. The present study is a one-arm trial that seeks to evaluate the efficacy in patients with unresectable ESCC. The study objectives include R0 resection rate, complete pathological response and treatment toxicity, etc. Nimotuzumab is a recombinant humanized monoclonal antibody against EGFR. Its efficacy and safety in patients with esophageal cancer have been confirmed by many studies. The current prospective phase II study aimed to evaluate the efficacy and safety of a combination regimen comprising chemotherapy with nimotuzumab with a dose of 800mg per week and S-1 and concurrent radiotherapy for patients who are elderly or malnourished.

Clinical Trial Description

n/a

Study Design

Related Conditions & MeSH terms

Clinical Trial Details
NCT number NCT06429839
Study type Interventional
Source Cancer Institute and Hospital, Chinese Academy of Medical Sciences
Contact Xin Wang, Doctor
Phone 13311583220
Email beryl_wx2000@163.com
Status Recruiting
Phase Phase 2
Start date March 1, 2023
Completion date December 31, 2026
View Details
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