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Colchicine for Patients With Chagas´ Disease( B1 Stage) — COACH  

Chagas Disease Clinical Trial

Official title:
Effect of Colchicine on Inflammation and Myocardial Fibrosis Assessed by Magnetic Resonance Imaging in Patients With Chagas' Heart Disease

Clinical Trial Summary

This study evaluate the addition of colchicine in the treatment of patients with Chagas´disease.

Forty patients will receive colchicine while twenty patients will receive placebo

Clinical Trial Description

Chagas disease is considered one of the main cause of dilated cardiomyopathy in Latin America. The histopathological characteristics of Chagas' disease are the presence of myocarditis, destruction of heart fibers, and severe myocardial fibrosis. Colchicine had a protective effect on myocardium, indicated by decreased interstitial myocardial fibrosis and attenuated myocardial inflammation. It is an inflammatory cause of cardiomyopathy and myocardial fibrosis is the hallmark of this disease. Colchicine is a drug used in inflammatory diseases, and could also act on myocardial remodeling interfering in the synthesis of collagen ;

Study Design

Related Conditions & MeSH terms

Clinical Trial Details
NCT number NCT03704181
Study type Interventional
Source University of Sao Paulo General Hospital
Contact Fabio Fernandes, MD, PHD
Phone +55 11 2661 5057
Email fabio.fernandes@incor.usp.br
Status Recruiting
Phase Phase 2
Start date October 1, 2018
Completion date January 5, 2021
View Details
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