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Clinical Trial Summary

The aim of this study is to estimate the role of ondansetron lozenge on prevention of post-spinal shivering in cesarean section.


Clinical Trial Description

Spinal anesthesia (SA) is preferred for cesarean section (CS) compared with general anesthesia(GA) because of several advantages, including prevention of the potential risk of GA-related neurotoxicity. Post-spinal shivering (PSS) could be a provocative factor for postoperative pain and its appropriate treatment prevents non-thermoregulatory tremors. Shivering also causes aggravating postoperative pain by stretching of sutures. Ondansetron is a selective antagonist for receptor 5-hydroxytryptamine 3 and is very effective in the prevention and treatment of shivering intra- and post-operation. Ondansetron can affect the body temperature and shivering in rats since the balance of nor-epinephrine and 5-hydroxytryptamine (5-HT) in the preoptic-anterior hypothalamus controls the temperature set point. ;


Study Design


Related Conditions & MeSH terms


NCT number NCT06423807
Study type Interventional
Source Tanta University
Contact Mohammed S Elsharkawy, MD
Phone 00201148207870
Email mselsharkawy@med.tanta.edu.eg
Status Recruiting
Phase N/A
Start date May 21, 2024
Completion date December 1, 2024

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