Misoprostol Versus Active Management of Labour in CS

Cesarean Section Clinical Trial

Official title:

Intrauterine Misoprostol With Active Management of Labour Versus Active Management of Labour for Prevebtion of Postpartum Hemorage in Cesarean Section ,Randomized Controlled Trial

Clinical Trial Details — Status: Completed

Administrative data

• NCT number: NCT03390010
• Other study ID #: Active management of labour
• Status: Completed
• Phase: Phase 1
• Start date: December 28, 2017
• Est. completion date: March 6, 2018

Study information

• Verified date: November 2022
• Source: Aljazeera Hospital
• Contact: n/a
• Is FDA regulated: No
• Study type: Interventional

Clinical Trial Summary

Several treatment strategies are emplemented to prevent post delivery hemorage and decreasing maternal morbidity and mortality .

Description:

Many approved drugs are used in prophylaxis against postpartum hemorage from these medications are the (syntocinon combined with methergine ) that are known as active management of labour drugs . Moreover there is misotac , that also guards against postpartum hemorage . All these medications act in a different way to cause uterine contraction post delivery to prevent uterine atony . -Here we are comparing the additive value of misotac intrauterine to syntocinon and methergine in comparison to the usually used syntocinon plus methergine .

Recruitment information / eligibility

• Status: Completed
• Enrollment: 300
• Est. completion date: March 6, 2018
• Est. primary completion date: February 28, 2018
• Accepts healthy volunteers: Accepts Healthy Volunteers
• Gender: Female
• Age group: 18 Years to 42 Years

Eligibility

Inclusion Criteria:

• • All patients included in this research were aged 18-42 years, pregnant 37 weeks till 42 weeks
• no medical disorders with pregnancy e.g DM, HTN. All patients were subjected to full history taking, examination.

Exclusion Criteria:

• Exclusion Criteria:
• The following patients were excluded , GA before 37 weeks or after 42 weeks , medical disorders with pregnancy eg. DM with pregnancy, HTN with pregnancy

Related Conditions & MeSH terms

• Cesarean Section

Intervention

Drug:
• Misoprostol + syntocinon and using extra uterotonic drugs when needed ; methergine
medical prophylaxis against postpartum atony and postpartum hemorage by giving misoprostol plus syntocinon and using extra uterotonic drugs when needed ; methergine, carboprost
• Syntocinon and using extra uterotonic drugs when needed ; methergine carboprost
medical prophylaxis against postpartum atony and postpartum hemorage by giving syntocinon and using extra uterotonic drugs when needed ; methergine, carboprost

Locations

Country	Name	City	State
Egypt	Algazeerah	Giza

Sponsors (2)

Lead Sponsor	Collaborator
Aljazeera Hospital	Cairo University

Country where clinical trial is conducted

Egypt, 

Outcome

Type	Measure	Description	Time frame	Safety issue
Primary	The number of participants who passed cesarean section without postpartum hemorage		within 2 days post CS