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NCT05595252 Clinical Trial

Retrospective Study on the Evolution of CIN 1 to 3 in Per and Postpartum in Nancy From 2014 to 2022

Cervical Intraepithelial Neoplasia Clinical Trial

Official title:
Retrospective Study on the Evolution of CIN 1 to 3 in Per and Postpartum in Nancy From 2014 to 2022

Clinical Trial Details — Status: Enrolling by invitation

Administrative data
NCT number NCT05595252
Other study ID # 2022PI157/EUDRACT
Secondary ID
Status Enrolling by invitation
Phase
First received
Last updated
Start date January 1, 2014
Est. completion date December 31, 2022

Study information
Verified date October 2022
Source Central Hospital, Nancy, France
Contact n/a
Is FDA regulated No
Health authority
Study type Observational

Clinical Trial Summary

In France, the screening rate for cervical cancer remains too low. Screening is simple and non-invasive. Pregnant patients are most of the time young and are part of the target population for screening, and for many women, it is the first encounter with a gynecologist. The cervical smear is therefore an important step of the first consultation during pregnancy In the case of pathological results, colposcopies with biopsies are performed, frequently finding CIN 1 to 3. (cervical intraepithelial neoplasia) These CIN lesions evolve slowly and most of the time, treatment can be withheld until the end of the pregnancy. Several studies suggest a higher regression rate in pregnant patients. Our study will evaluate the rate of regression, progression or persistence of these lesions in per and post partum patients in Nancy, between 2014 and 2022. To obtain our results, we will compare the results of per and post partum biopsies in each patient. In a second step, we will study the risk factors of aggravation or on the contrary the protective factors, allowing a faster regression of the lesions

Recruitment information / eligibility
Status Enrolling by invitation
Enrollment 100
Est. completion date December 31, 2022
Est. primary completion date December 1, 2022
Accepts healthy volunteers Accepts Healthy Volunteers
Gender Female
Age group N/A and older
Eligibility Inclusion Criteria: - women who have a CIN lesion during pregnancy - in Nancy, France, MRUN Center - between 2014 and 2022 Exclusion Criteria: - lost of follow up women

Study Design

Related Conditions & MeSH terms

Intervention

Biological:
• cervical biopsy
cervical biopsy made during and after pregancy

Locations
Country Name City State
France BENOIT Camille Nancy

Sponsors (1)
Lead Sponsor Collaborator
Central Hospital, Nancy, France

Country where clinical trial is conducted

France, 

Outcome
Type Measure Description Time frame Safety issue
Primary progress, persistence or regression of CIN lesion count cervical biopsy up to one year after delivery
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