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Clinical Trial Details — Status: Completed

Administrative data

NCT number NCT02894359
Other study ID # SSA_2016_19
Secondary ID
Status Completed
Phase
First received
Last updated
Start date October 27, 2016
Est. completion date October 25, 2018

Study information

Verified date January 2019
Source Fondation Ophtalmologique Adolphe de Rothschild
Contact n/a
Is FDA regulated No
Health authority
Study type Observational

Clinical Trial Summary

Cervical dystonia (CD) is a syndrome characterized by sustained and/or phasic involuntary neck muscle activity causing abnormal head postures and movements. It is the most frequent form of adult focal dystonia. The distribution of dystonic muscles is unique for each patient, explaining the variety of patterns encountered.

The therapeutic management of CD is essentially local and symptomatic: Botulinum Neurotoxin injections and/or specific retraining therapy programmes. Therefore, analyzing the characteristics of abnormal head movements and identifying the dystonic muscles are the key points of these treatments.

To a better understanding of the posture and movement disorders of head and neck, we wish to establish a three-dimensional (3-D) computer model of cervical spine movements of ten healthy subjects built from images obtained with the "Cone Beam " system. Then we will compare the cervical posture and movements for each of ten CD patients matched in age and genre to the computer model. Comparison with patients' images in the axial plane reconstructed by computer with the 3-D computer model will lead to the description of various patterns of CD. Analysis of the musculoskeletal disturbances in CD should be a help to improve the localization of Botulinum Neurotoxin injection sites as well as retraining programmes.


Recruitment information / eligibility

Status Completed
Enrollment 21
Est. completion date October 25, 2018
Est. primary completion date October 25, 2018
Accepts healthy volunteers Accepts Healthy Volunteers
Gender All
Age group 18 Years to 70 Years
Eligibility Inclusion Criteria:

- Tonic form of focal or segmental cervical dystonia (diagnostic confirmed by a neurologist specialized in movement disorders) for CD patients, or absence of CD for control subjects

- absence of treatment by botulinum neurotoxin, or last injection > 3 months

- age > 18 and < 71 years

- informed consent

- medical insurance coverage

Exclusion Criteria:

- CD mobile (clonic) and/or head tremor

- patient unable to sit without moving the head during the examination (x-ray pictures with cone beam)

- Other neurological disease with effect on the posture and/or movement of the cervical region

- Pain or traumatism of the cervical region requiring medical or surgical treatment in the preceding 6 months

- Pregnant or breast feeding patient

- Participation in another research with a potential impact on evaluation criteria

- patient under judiciary protection

Study Design


Intervention

Device:
cone beam imagery of cervical spine


Locations

Country Name City State
France Fondation Ophtalmique Adolphe de Rothschild Paris

Sponsors (1)

Lead Sponsor Collaborator
Fondation Ophtalmologique Adolphe de Rothschild

Country where clinical trial is conducted

France, 

Outcome

Type Measure Description Time frame Safety issue
Primary comparison of bone marks positions (degrees) in patients ans control motions positions measured in degrees with computerized imaging baseline
See also
  Status Clinical Trial Phase
Completed NCT03938363 - Analysis of Gait Before and After Botulinum Toxin Treatment in Patients With Focal Dystonia N/A
Terminated NCT02837185 - Effects of Botulinum Toxin on Muscle and Brain Activity N/A