Cervical Dystonia, Primary Clinical Trial
— STICOBVerified date | January 2019 |
Source | Fondation Ophtalmologique Adolphe de Rothschild |
Contact | n/a |
Is FDA regulated | No |
Health authority | |
Study type | Observational |
Cervical dystonia (CD) is a syndrome characterized by sustained and/or phasic involuntary
neck muscle activity causing abnormal head postures and movements. It is the most frequent
form of adult focal dystonia. The distribution of dystonic muscles is unique for each
patient, explaining the variety of patterns encountered.
The therapeutic management of CD is essentially local and symptomatic: Botulinum Neurotoxin
injections and/or specific retraining therapy programmes. Therefore, analyzing the
characteristics of abnormal head movements and identifying the dystonic muscles are the key
points of these treatments.
To a better understanding of the posture and movement disorders of head and neck, we wish to
establish a three-dimensional (3-D) computer model of cervical spine movements of ten healthy
subjects built from images obtained with the "Cone Beam " system. Then we will compare the
cervical posture and movements for each of ten CD patients matched in age and genre to the
computer model. Comparison with patients' images in the axial plane reconstructed by computer
with the 3-D computer model will lead to the description of various patterns of CD. Analysis
of the musculoskeletal disturbances in CD should be a help to improve the localization of
Botulinum Neurotoxin injection sites as well as retraining programmes.
Status | Completed |
Enrollment | 21 |
Est. completion date | October 25, 2018 |
Est. primary completion date | October 25, 2018 |
Accepts healthy volunteers | Accepts Healthy Volunteers |
Gender | All |
Age group | 18 Years to 70 Years |
Eligibility |
Inclusion Criteria: - Tonic form of focal or segmental cervical dystonia (diagnostic confirmed by a neurologist specialized in movement disorders) for CD patients, or absence of CD for control subjects - absence of treatment by botulinum neurotoxin, or last injection > 3 months - age > 18 and < 71 years - informed consent - medical insurance coverage Exclusion Criteria: - CD mobile (clonic) and/or head tremor - patient unable to sit without moving the head during the examination (x-ray pictures with cone beam) - Other neurological disease with effect on the posture and/or movement of the cervical region - Pain or traumatism of the cervical region requiring medical or surgical treatment in the preceding 6 months - Pregnant or breast feeding patient - Participation in another research with a potential impact on evaluation criteria - patient under judiciary protection |
Country | Name | City | State |
---|---|---|---|
France | Fondation Ophtalmique Adolphe de Rothschild | Paris |
Lead Sponsor | Collaborator |
---|---|
Fondation Ophtalmologique Adolphe de Rothschild |
France,
Type | Measure | Description | Time frame | Safety issue |
---|---|---|---|---|
Primary | comparison of bone marks positions (degrees) in patients ans control motions | positions measured in degrees with computerized imaging | baseline |
Status | Clinical Trial | Phase | |
---|---|---|---|
Completed |
NCT03938363 -
Analysis of Gait Before and After Botulinum Toxin Treatment in Patients With Focal Dystonia
|
N/A | |
Terminated |
NCT02837185 -
Effects of Botulinum Toxin on Muscle and Brain Activity
|
N/A |