Toripalimab Combined With Definitive CCRT for LACC Patients

Status Recruiting

Clinical Trial Summary

Cervical cancer constitutes a significant health burden for women globally. While most patients with early-stage disease can be cured with radical surgery or chemoradiotherapy, patients with high-risk locally advanced disease or with recurrent/metastatic disease have a poor prognosis with standard treatments. Immunotherapies are a rational treatment for this HPV-driven cancer that commonly expresses programmed cell death ligand-1. Toripalimab, a humanized immunoglobulin G4 monoclonal antibody against PD-1, showed promising anti-tumor efficacy in multiple solid tumors. This randomised study is evaluating toripalimab combined with CCRT versus CCRT alone for treatment-naïve LACC.

Clinical Trial Description

n/a

Study Design

Related Conditions & MeSH terms

Clinical Trial Details

NCT number	NCT06256224
Study type	Interventional
Source	Ruijin Hospital
Contact	Dan Ou
Phone	8618801970632
Email	od12341@rjh.com.cn
Status	Recruiting
Phase	N/A
Start date	February 2, 2024
Completion date	December 31, 2028

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